Journal of Dali University ›› 2021, Vol. 6 ›› Issue (2): 86-89.DOI: 10. 3969 / j. issn. 2096-2266. 2021. 02. 019
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Zhang Yulin1, Ai Zhiqiong1, Lu Ang1, Xie Kexin2, Li Fuxing2, Wu Xiumei1*
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Abstract: Objective: To dynamically analyze the distribution and drug resistance of Pseudomonas aeruginosa isolated from clinical samples of the First Affiliated Hospital of Dali University from 2015 to 2019, and to provide reference in rational antibiotics use for clinicians. Methods: Routine isolation and culture, strain identification and drug sensitivity test were carried out on the clinical samples collected during 2015 to 2019. The data were analyzed with WHONET 5.6 and SPSS 20.0 software. Results: A total of 609 PAE non-repetitive strains were isolated in the hospital from 2015 to 2019, and the numbers of PAE strains isolated increased year by year. Among them, the samples with the highest detection rate were sputum, followed by secretions and alveolar lavage fluid. Meanwhile, the top three departments of isolated PAE were Respiratory Medicine, ICU and Pediatrics. The results of the drug susceptibility test showed that the overall resistance rate of PAE to imipenem, ceftazidime, cefoperazone/sulbactam, gentamicin and cefepime showed a trend change during 5 years, and the difference in resistance rate between the years was statistically significant(P < 0.05). Its resistance rate to nitrofurantoin and compound sulfamethoxazole did not change significantly, but the resistance rate to amikacin fluctuated in the 5 years. Conclusion: The trend of antibiotics resistance of PAE was stable in the past 5 years. The dynamic monitoring of bacterial drug resistance should be strengthened to guide the rational use of antibiotics in clinic.
Key words: Pseudomonas aeruginosa, drug resistance, antibiotics, dynamic monitoring
CLC Number:
R725.6
Zhang Yulin, Ai Zhiqiong, Lu Ang, Xie Kexin, Li Fuxing, Wu Xiumei. Dynamic Analysis on Distribution and Drug Resistance of Pseudomonas aeruginosa in a Hospital#br# from 2015 to 2019[J]. Journal of Dali University, 2021, 6(2): 86-89.
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URL: http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/10. 3969 / j. issn. 2096-2266. 2021. 02. 019
http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/Y2021/V6/I2/86