Study on the Mechanism of Ophiocordyceps sinensis in Treating Liver Cirrhosis Based on Network Pharmacology

doi:10. 3969 / j. issn. 2096-2266. 2021. 08. 004

Abstract

Abstract: Objective: To analyze and explore the main active components, main targets, key pathways and mechanisms of
Ophiocordyceps sinensis in the treatment of liver cirrhosis by using network pharmacology methods. Methods: The potential targets
and main active components of Ophiocordyceps sinensis were captured from the TCMSP database; the main targets of liver cirrhosis were
obtained from the GeneCards database; a component-target network was constructed by Cytoscape 3.2.1 software; a protein-protein
interaction network(PPI) was constructed by STRING database; DAVID database was used for GO function enrichment and KEGG
pathway enrichment analyses. Results: 87 potential targets, 6 main active ingredients and 56 liver cirrhosis targets were obtained. The
PPI network contained 45 proteins, involving MAPK1, CASP8, etc. KEGG pathway enrichment analysis yielded 44 signal pathways
(FDR<0.01), involving pathways in cancer, Hepatitis B, etc, and GO functional enrichment analysis yielded 23 entries (P<0.01).
Conclusion: This study uses network pharmacology to preliminarily predict the mechanism of Ophiocordyceps sinensis in the
treatment of liver cirrhosis, which provides new ideas for subsequent in-depth research.

Key words: network pharmacology, Ophiocordyceps sinensis, liver cirrhosis, mechanism of action

CLC Number:

R285.5

Li Jie, Chen Yichun, Li Jufa, Chen Lintao, Wang Jiazhe, Jiang Yina, Zhang Bintao. Study on the Mechanism of Ophiocordyceps sinensis in Treating Liver Cirrhosis Based on Network Pharmacology[J]. Journal of Dali University, 2021, 6(8): 16-21.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/10. 3969 / j. issn. 2096-2266. 2021. 08. 004

http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/Y2021/V6/I8/16

References

〔1〕陈龙, 慕永平, 张华, 等. 一贯煎干预肝硬化作用机制
研究进展〔J〕. 中国实验方剂学杂志, 2020, 26(24):
186-192.

〔2〕陈震, 夏红, 李丽, 等. 水解蛋白口服溶液治疗肝硬

化低蛋白血症疗效研究〔J〕. 现代医药卫生, 2020,
36(19): 3072-3074.
〔3〕孙昳, 陈莉萍. 舒肝宁注射液联合替诺福韦治疗慢性
乙型肝炎肝硬化的临床研究〔J〕. 现代药物与临床,
2020, 35(9): 1791-1794.
〔4〕胡贤达, 岳颖, 武鹏, 等. 冬虫夏草治疗肝脏疾病的药
理作用〔J〕. 临床肝胆病杂志, 2016, 32(4): 793-797.
〔5〕崔兵兵, 李季, 刘可春, 等. 冬虫夏草多糖抑制肝纤维
化作用机制的研究进展〔J〕. 中国实验方剂学杂志,
2019, 25(15): 228-234.
〔6〕陈博威, 易健, 刘柏炎, 等. 基于网络药理学与分子对
接探讨黄芪- 女贞子药对治疗阿尔茨海默病的作用机
制〔J〕. 天然产物研究与开发, 2020, 32(12): 2040-2050.
〔7〕陈纪烨, 张永健, 姜萍, 等. 基于网络药理学的五苓
散治疗慢性心力衰竭的机制研究〔J〕. 中草药, 2020,
51(20): 5220-5227.
〔8〕KHATUN M S, BISWAS M H A. Optimal Control
Strategies for Preventing Hepatitis B Infection and
Reducing Chronic Liver Cirrhosis Incidence〔J〕. Infect
Dis Model, 2019, 5: 91-110.
〔9〕王啸, 高亚丽. 长期抗病毒治疗对乙型肝炎肝硬化
患者预后及转归的影响〔J〕. 中国实用医药, 2020,
15(27): 4-7.
〔10〕王恒忠. 甘草酸二铵肠溶胶囊联合恩替卡韦治疗乙
肝肝硬化的效果〔J〕. 中国继续医学教育, 2020,
12(29): 134-137.
〔11〕柯建辉. 白蛋白联合呋塞米治疗肝硬化腹水患者的
效果及并发症发生情况分析〔J〕. 中外医学研究,
2020, 18(28): 58-60.
〔12〕HISHIKAWA D, YANAGIDA K, NAGATA K, et al.
Hepatic Levels of DHA-Containing Phospholipids
Instruct SREBP1-Mediated Synthesis and Systemic
Delivery of Polyunsaturated Fatty Acids〔J〕.
iScience, 2020, 23(9): 101495.
〔13〕俞发荣, 杨博, 连秀珍, 等. 十八烯酸对人胃癌组
织的靶向作用〔J〕. 中国临床药理学杂志, 2017,
33(6): 539-541.
〔14〕余焕玲, 毕研霞, 肖荣, 等. β谷固醇对高脂饲料喂养
小鼠空间学习记忆能力的影响〔J〕. 首都医科大学
学报, 2008, 29(6): 724-727.
〔15〕SHIN E J, CHOI H K, SUNG M J, et al. Anti-
Tumour Effects of Beta-Sitosterol Are Mediated by
AMPK/PTEN/HSP90 Axis in AGS Human Gastric
Adenocarcinoma Cells and Xenograft Mouse Models〔J〕.
Biochem Pharmacol, 2018, 152: 60-70.
〔16〕李如意, 宋厚盼, 魏艳霞, 等. 冬虫夏草药理作用
的研究进展〔J〕. 环球中医药, 2016, 9(10): 1284-
1288.
〔17〕GUO H, ZHOU H, LU J, et al. Vascular Endothelial
Growth Factor: An Attractive Target in the Treatment
of Hypoxic/Ischemic Brain Injury〔J〕. Neural Regen
Res, 2016, 11(1): 174-179.

[1]	Gao Xiaomin, Zhao Qin. Application of Network Pharmacology to Predict the Mechanism of Semen Cassiae#br# in the Treatment of Hypertension [J]. Journal of Dali University, 2021, 6(8): 11-15.
[2]	Liu Xiangfang, Wang Lu, Chen Jie, Sun Hui, Lu Shaoyu, Liu Xing. Study on the Mechanism of Ranunculus ternatus in the Treatment of Pulmonary Tuberculosis Based on#br# Network Pharmacology [J]. Journal of Dali University, 2021, 6(2): 39-45.
[3]	Suo Guangxi, Hu Changxiao, Xiao Tianbao. The Mechanism of Tongxie-Yaofang in Treating Inflammatory Bowel Disease Based on#br# Network Pharmacology [J]. Journal of Dali University, 2021, 6(2): 46-50.
[4]	XU Ya, DIAO Qi. Study on the Mechanism of Antihypertensive Effect of Plantain Seed Based on Network Pharmacology [J]. , 2019, 4(8): 33-38.
[5]	Xu Feng, Chen Teng, Wang Zuhua, Huang Xulong. Study on the Anti-diabetes Mechanism of Polygonati Rhizoma Based on Network Pharmacology [J]. Journal of Dali University, 2019, 4(2): 21-.
[6]	WEN Jian-Xia, LI Yang, HAO Dun-Jie. Study on the Mechanism of Coptidis Rhizoma-Aucklandiae Radix on the Treatment of Ulcerative Colitis Based on Network Pharmacology [J]. , 2019, 4(10): 32-39.
[7]	ZHANG Le, LI Yang, HAO Dun-Jie. Study on the Mechanism of Herb Pair "Ephedrae- Cinnamomi" in the Treatment of Colds Based on Network Pharmacology [J]. , 2019, 4(10): 40-45.
[8]	LI Yang, ZHANG Le, HAO Dun-Jie. Anti-inflammatory Activity Analysis of Gentiana macrophylla Based on Network Pharmacology [J]. , 2019, 4(10): 46-51.
[9]	Li Yang, Hao Junjie. Network Pharmacology-based Study on Mechanism of DangGuiBuXue Decoction in Treating Anemia [J]. , 2018, 3(10): 1-6.
[10]	Hao Junjie, Li Yang. A Study on Therapeutic Mechanism of Ephedrae Herba-Cinnamomi Ramulus Herbal Pair in Treating Hydropsy [J]. , 2018, 3(10): 7-12.