Initial Treatment of Pseudomonas aeruginosa Keratitis with Topical Chloramphenicol and Effects#br#
on Prognosis

doi:10. 3969 / j. issn. 2096-2266. 2021. 08. 019

Abstract

Abstract: Objective: To determine whether the initial use of chloramphenicol for empirical treatment of Pseudomonas aeruginosa
keratitis has a positive effect on its prognosis. Methods: 77 patients (77 eyes) from January 2014 to December 2019, bacterial cultured
and identified as bacterial infection by Pseudomonas aeruginosa in the ophthalmology department of Dali Bai Autonomous Prefecture
People s Hospital were retrospectively analyzed. According to the use of chloramphenicol eye drops before levofloxacin eye drops,
they were divided into chloramphenicol group and non-chloramphenicol group. The ulcer area, the initial best corrected visual acuity, the
final best corrected visual acuity, the course of the disease and the complications when starting to use levofloxacin eye drops were
recorded in details. Results: 36.36% of patients used chloramphenicol eye drops before levofloxacin drops. The ulcer area in the
chloramphenicol group was larger (P<0.05), and the initial best corrected visual acuity and final best corrected visual acuity of the two
groups had no statistically significant difference. The course of the disease was longer in the chloramphenicol group (P<0.05). The
rates of corneal pannus and corneal perforation in the chloramphenicol group and non-chloramphenicol group were 3.57% and 2.04%,
respectively (P>0.05). There was no correlation between the area of the ulcer and the initial best corrected visual acuity (r <0.2). The
length of the disease has a certain correlation with the area of the ulcer, the initial best corrected visual acuity and the final best
corrected visual acuity (0.2 <r <0.4). The final best corrected visual acuity has a strong correlation with the initial best corrected visual
acuity (r> 0.6). Conclusion: More than 1/3 Pseudomonas aeruginosa keratitis patients used chloramphenicol eye drops before using
levofloxacin eye drops, but using chloramphenicol eye drops did not improve the patient s ultimate corrective vision, shorten course, or
reduce the incidence of complications.

Key words: keratitis, Pseudomonas aeruginosa keratitis, chloramphenicol eye drops, levofloxacin eye drops

CLC Number:

Mo Ni, Zheng Zhimei, Li Tingna, Li Guixiang, Yu Deshun. Initial Treatment of Pseudomonas aeruginosa Keratitis with Topical Chloramphenicol and Effects#br# on Prognosis[J]. Journal of Dali University, 2021, 6(8): 81-84.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/10. 3969 / j. issn. 2096-2266. 2021. 08. 019

http://journal15.magtechjournal.com/Jwk_dlxyzk/EN/Y2021/V6/I8/81

References

〔1〕WHITCHER J P, SRINIVASAN M, UPADHYAY M
P. Corneal Blindness: A Global Perspective〔J〕. Bull
World Heal Organ, 2001, 79(3): 214-221.
〔2〕PASCOLINI D, MARIOTTI S P. Global Estimates of
Visual Impairment: 2010〔J〕. Br J Ophthalmol, 2012,
96(5): 614-618.
〔3〕GUPTA N, TANDON R, GUPTA S K, et al. Burden of
Corneal Blindness in India〔J〕. Indian J Community
Med, 2013, 38(4): 198-206.
〔4〕UBANI-UKOMA U, GIBSON D, SCHULTZ G, et al.
Evaluating the Potential of Drug Eluting Contact Lenses
for Treatment of Bacterial Keratitis Using an ex vivo
Corneal Model〔J〕. Int J Pharm, 2019, 565(3): 499-
508.
〔5〕BOGRAD A, SEILER T, DROZ S, et al. Bacterial and
Fungal Keratitis: A Retrospective Analysis at a University
Hospital in Switzerland〔J〕. Klinische Monatsblatter

Fur Augenheilkunde, 2019, 236(4): 358-365.

〔6〕GREEN M, APEL A, STAPLETON F. Risk Factors
and Causative Organisms in Microbial Keratitis〔J〕.
Cornea, 2008, 27(1): 22-27.
〔7〕KEAY L, STAPLETON F, SCHEIN O. Epidemiology
of Contact Lens-Related Inflammation and Microbial
Keratitis: A 20-Year Perspective〔J〕. Eye Contact
Lens, 2007, 33(6): 346-353.
〔8〕钟文贤, 孙士营, 赵靖, 等. 1 054 例化脓性角膜炎的回
顾性分析〔J〕. 中华眼科杂志, 2007, 43(3): 245-250.
〔9〕SAND D, SHE R, SHULMAN I A, et al. Microbial
Keratitis in Los Angeles: The Doheny Eye Institute and
the Los Angeles County Hospital Experience〔J〕.
Ophthalmology, 2015, 122(5): 918-924.
〔10〕AUSTIN A, LIETMAN T, ROSE-NUSSBAUMER J.
Update on the Management of Infectious Keratitis〔J〕.
Ophthalmology, 2017, 124(11): 1678-1689.
〔11〕RACHWALIK D, PLEYER U. Bakterielle Keratitis 〔J〕.
Klin Monbl Augenheilkd, 2015, 232(6): 738-744.
〔12〕王智群, 张阳, 孙旭光. 2007—2013 年眼部细菌培养
阳性菌株的分布及其耐药性分析〔J〕. 眼科, 2015,
24(4): 262-267.
〔13〕JENG B H, GRITZ D C, KUMAR A B, et al. Epidemiology
of Ulcerative Keratitis in Northern California〔J〕.
Arch Ophthalmol, 2010, 128(8): 1022-1028.
〔14〕TUFT S J, MATHESON M. In vitro Antibiotic Resistance
in Bacterial Keratitis in London〔J〕. Br J Ophthalmol,
2000, 84(7): 687-691.
〔15〕ORLANS H O, HORNBY S J, BOWLER I C. In vitro
Antibiotic Susceptibility Patterns of Bacterial Keratitis
Isolates in Oxford, UK: A 10-Year Review〔J〕. Eye
(Lond), 2011, 25(4): 489-493.
〔16〕PEARCE F, WONG N, CHAN E. Incidence of
Chloramphenicol Use and the Effect on Corneal
Scrape Results in Bacterial Keratitis〔J〕. Clin Exp
Ophthalmol, 2016, 44(9): 868-869.
〔17〕BOURKIZA R, KAYE S, BUNCE C, et al. Initial
Treatment of Pseudomonas aeruginosa Contact Lens-
Associated Keratitis with Topical Chloramphenicol,
and Effect on Outcome〔J〕. Br J Ophthalmol, 2013,
97(4): 429-432.

[1]	Zhou Jin, Yao Lei, Liu Jun, Ye Longling, Zhang Yi, Chen Jin. Analysis of Multiple Gene Sequencing Results of Primary Open-Angle Glaucoma with#br# Hereditary Ophthalmopathy [J]. Journal of Dali University, 2021, 6(2): 67-71.
[2]	Chen Gang, Du Mei, Li Yiqing, Li Meijun, Liu Liqing. Analysis of the Eye Diseases Screening Results of 933 Newborns by Ret Cam III [J]. J4, 2016, 1(10): 54-56.
[3]	Duan Zhiguang, Jia Yunqin, Mo Ni, Yu Liyun, Chen Yingchao, Liu Min, Pu Shixue, Z. Clinical Observation of Bevacizumab in the Treatment of Diabetic Macular Edema [J]. J4, 2016, 1(4): 55-59.
[4]	Zhao Huiqiong. Clinical Analysis of 87 Cases of Surgical Correction of Congenital Blepharoptosis [J]. J4, 2016, 1(4): 60-63.
[5]	Zhu Hongfen, Wang Kaimei, Zhang Jin. Clinical Efficacy of Amniotic Membrane Transplantation Treating Pterygium [J]. J4, 2016, 15(2): 41-44.
[6]	Yu Liyun, Mo Ni, Jia Yunqin, Liu Min, Pu Shixue. Clinical Analysis of 27 Cases of Preschool Children with Ocular Trauma in Dali Region [J]. J4, 2015, 14(4): 53-56.
[7]	Zhao Huiqiong, Dong Liping. A Study of Pathogenic Related Factors of Neonatal Dacryocystitis in Yuxi [J]. J4, 2015, 14(2): 33-35.
[8]	LI Mei-Jun, ZHANG Hong. Value Analysis of Noninvasive Positive Pressure Ventilation in the Treatment of Preterm Infants with Respiratory Distress Syndrome [J]. J4, 2014, 13(8): 31-32.
[9]	HE Ya-Ni, CHEN Yin-Chao. A Clinical Analysis of 57 Cases of Microsurgery for Lacrimal Ductile Tear [J]. J4, 2014, 13(4): 47-49.
[10]	WANG Xiang-Zhen, MA Na-Na. The Relationship between HSP47 and Intrauterine Adhesions and Its Significance in Fibrosis Diseases [J]. J4, 2014, 13(4): 59-62.
[11]	DUAN Zhi-Guang, YU Li-Yun, CHEN Yin-Chao, JIA Yun-Qin, MO Ni. Application of 23-gauge Micro-invasive Vitrectomy for Vitreoretinopathy Disease [J]. J4, 2014, 13(2): 47-51.
[12]	ZHAO Wei, MA Mai-Cong, YIN Zhi-Jian, LI Cai-Rui. [J]. J4, 2013, 12(6): 60-61.
[13]	LIU Yu-Zhu, LIN Can-Song, HE She-Ji. Analysis of Vision Testing for Primary and Middle School Students from 1991 to 2010 in Dali Prefecture [J]. J4, 2012, 11(12): 35-39.
[14]	ZHANG Zi-Yan, JIANG Yun-Kun. Clinical Observation of 24 Patients with Corneal Endotheliitis Syndrome [J]. J4, 2012, 11(12): 55-57.
[15]	ZHAO Hui-Qiong, YANG Yong-Fu, LIU Sha-Li, LIN Lan-Zhen, WANG Wen-Ji. Clinical Analysis of Six Cases of Reconstructive Surgery of Orbital Blowout Fracture [J]. J4, 2012, 11(6): 46-49.

Initial Treatment of Pseudomonas aeruginosa Keratitis with Topical Chloramphenicol and Effects#br# on Prognosis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments