Protective Effects of Periplaneta Americana Extract CII-3 against Acute Hepatic Injury Induced by Alcohol in Rats

Abstract

Abstract:

Objective: To investigate the protective effects of CII-3, which was extracted from Periplaneta americana against acute hepatic injury induced by alcohol in rats. Methods: The rat model of acute hepatic injury was induced by stomach perfusion with 56⁰Red Star Liquor for 10 days and different doses of CII-3 treatment. At the 11th day of the treatment, the ALT, AST, TG in rat serum and GSH, SOD, MDA in liver homogenate were measured. At the end of the treatment, the rats were euthanized and the hepatic tissues were conduct to the histopathological examination. Results: Compared with the control group, CII-3 treatment could remarkably reduce the levels of ALT, AST, TG and MDA (P<0.01), and increase the levels of SOD and GSH (P<0.01); furthermore, CII-3 treatment could mitigate hepatocyte fatty degeneration, cellular necrosis and inflammatory infiltration. Conclusion: CII-3 extracted from Periplaneta americana may prevent rats from acute hepatic injury induced by alcohol.

Key words: Periplaneta americana, alcohol-induced hepatic injury, protective action

CLC Number:

R285.5

ZHANG Xu-Qiang, HE Xu, CHEN Jun-Ya, HU Wen-Shuai, PENG Fang. Protective Effects of Periplaneta Americana Extract CII-3 against Acute Hepatic Injury Induced by Alcohol in Rats[J]. J4, 2011, 10(12): 1-5.

References

〔1〕Moriarty K J，Platt H，Crompton S，et al. Collaborative care
for alcohol-related liver disease〔J〕. Clin Med，2007，7
（2）：125-128.
〔2〕Bruhar，Dvoak K，Dousa M，et al. Alcoholic liver disease
〔J〕. Prague Med Rep，2009，110（3）：181-190.
〔3〕赵可，李弼民. 酒精性肝病的研究进展〔J〕. 实用临床医
学，2006，7（12）：194-197.
〔4〕蓝江林，周先治，卓侃，等. 美洲大蠊（Periplaneta americana）
抗菌肽杀菌作用初步观察〔J〕. 福建农林大学学报：自然
科学版，2004，33（2）：166.
〔5〕何正春，彭芳，宋丽艳，等. 美洲大蠊化学成分及药理作
用研究进展〔J〕. 中国中药杂志，2007，32（21）：2326-
2331.
〔6〕杜一民，陈鸿珊，李树楠，等. 治疗乙型肝炎新药肝龙胶
囊的药效学初步研究〔J〕. 时珍国医国药，2006，17
（8）：1369-1371.
〔7〕高永翔，扈晓宇，钟森，等. 蟑螂提取物抗肝损伤及抗病
毒作用探讨〔J〕. 国际中医中药杂志，2006，28（3）：155-
158.
〔8〕李武，段丽芳，何贵清，等. 美洲大蠊提取物对实验性肝
纤维化的影响〔J〕. 时珍国医国药，2010，21（5）：1137-
1138.
〔9〕甘平，张旭强，何旭，等. 美洲大蠊醇提物对小鼠急性肝
损伤的保护作用〔J〕. 现代药物与临床，2011，17（8）：123-
128.
〔10〕Lalor P F，Faint J，Aarbodem Y，et al. The role of cytokines
and chemokines in the development of steatohepatitis〔J〕.
Senin Liver Dis，2007，27（2）：173-193.
〔11〕Rouach H，Fataccioli V，Gentil M，et al. Effect of
chronicethano feeding on lipid peroxidation and protein
oxidation in relation to live pathology〔J〕. Hepatology，
1997，65（5）：351-355.
〔12〕Teare J P，Greenfield S M，Watson D，et al. Lipid
peroxidation in rats chronically fed ethanol〔J〕. Gut，
1994，35（1）：1644-1647.
〔13〕曲海波，宗建成，王海苹，等. 乌丹醒肝颗粒对大鼠急性
酒精性肝损伤的影响〔J〕. 齐鲁药事，2006，25（12）：757.
〔14〕王宪龄，卢依平. 柴胡黄芩配伍抗大鼠急性酒精性肝损
伤作用研究〔J〕. 中药药理与临床，2005，21（4）：10.
〔15〕Suchy J，Sokol R J，Balislreri W F. Liver disease in
children〔M〕. 2th ed. Philadelphia：JB Lippincott 2001：
155-169.

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