Abstract:

Objective: To compare the lead excretion effect of smilax glabra and garlic oil, and provide the theoretical evidence to
prevent lead poisoning. Methods: Lead poisoning model was constructed by lead acetate solution (40 mg/L) lavage at the standard of
0.01 mL/g weight for 15 days. After the lead exposure, 48 mice were randomly divided into 4 groups treated with smilax glabra, garlic
oil, EDTA and distilled water respectively for 15 days. Mice weights and lead concentrations were recorded before the lead poisoning,
the 16th day and the 31st day. Lead concentrations of tail vein blood were determined by the method of graphite furnace atomic
absorption. Results: 1. With different treatment, there were significant differences on the lead content in the blood among smilax
glabra group, EDTA group, garlic oil group and distilled water group (P<0.01). After the therapy of the lead excreation, the blood lead
content in smilax glabra group<EDTA group<garlic oil group< distilled water group. 2. Compared to the distilled water group, there
were both significant differences in weight of smilax glabra group and garlic oil group (P<0.05); the weight of the smilax group was
heavier than that of the garlic oil group (P<0.05). 3. Compared to the distilled water group, there were both significant differences in
survival rate of smilax glabra group and garlic oil group (P<0.05); there was no statistical difference on the survival rate of the smilax
glabra group and garlic oil group (P>0.05). Conclusion: Smilax glabra and garlic oil can promote the excretion of lead, our data
showed better lead excretion effect of Smilax glabra compared to the garlic oil.

Key words: smilax glabra, garlic oil, EDTA, lead poisoning, mice