Abstract:

Objective: To investigate the clinical distribution and drug resistance of four kinds of Gram-negative bacillus in
Affiliated Hospital of Dali University and provide basis for clinical medicine. Methods: VITET-2 compact automated microbial
analyzer was applied for bacterial identification, K-B disk diffusion method were used for drug sensitive test. Results: The drug
resistance rates of four kinds of bacilli to penicillins, sulfonamides, quinolones and amoxicillin amoxicillin/clavulanic acid, gentamicin,
cephalosporins, aztreonam, resistance rates were 75%、75%、20%、70%、55%、50%、13%, respectively. P. aeruginosa was more
sensitive to ceftazidime (7.22%) and cefepime (11.86%). E. coli and K. pneurmoniae were sensitive to both carbapenem and
cefoperazone/sulbactam, while P. aeruginosa were resistant to both carbapenem and cefoperazone/sulbactam, A. baumanii was
sensitive to imipenem and cefoperazone/sulbactam. E. coli and P. aeruginosa were sensitive to amikacin, K. pneurmoniae was sensitive
to piperacillin / tazobactam, but was resistance to others （>14%）. Conclusion: There were high drug resistences of 4 Gram-negative
bacillus in affiliated hospital of Dali University, hospital should be strengthened infection control, drug monitoring and clinical use of
antimicrobial drugs, reducing the emergence of resistant or multi-drug-resistant strains.

Key words: G-negative bacillus, E. coil, K. pneurmoniae, A. baumanii, P. aeruginosa, drug-resistance