Abstract:

Objective: To explore clinical application and significance of prenatal screening and diagnosis. Methods: Time-resolved method was used with serum AFP, β- HCG as indicators in 4 760 pregnant women with pregnancy15-20+6weeks for prenatal screening. For high risk pregnant women, genetic counseling and prenatal diagnosis were provided, and in the postpartum period, the delivery outcome follow-up observation was done. Results: In the follow-up, we found 29 cases of varying degrees of deformity, abortion, stillbirth and other adverse pregnancy outcomes. 6 cases were of high risk; 23 were of low risk. The amniotic fluid chromosome abnormalities existed in 2 cases; ultrasonic examination in detection of various malformations: open neural tube defects such as spina bifida, microcephaly, encephaloc in 6 cases; visceral malformations such as congenital heart disease, renal dysplasia, intrauterine fetal growth abnormalities in 5 cases; an unexplained stillbirth, late abortion in 3 cases. 21- trisomy 1 newborn in 1 case （prenatal screening for Down's risk to the amniotic fluid puncture cytology）. Conclusion: Prenatal screening and prenatal diagnosis can decrease the incidence of birth defects.