J4 ›› 2013, Vol. 12 ›› Issue (12): 1-4.

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Study of the Effect of Myrobalan Bark Extracts on Isolated Rat Uterus

  

  1. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China
  • Received:2013-08-28 Revised:2013-09-17 Online:2013-12-15 Published:2013-12-15

Abstract:

Objective: To research the effect of extracts (water extract and alcohol extract form myrobalan)on isolated rat uterus.
Methods: Observe the influence of water extract and alcohol extract from myrobalan on the spontaneous contraction of isolated rat uterus, and the isolated rat uterus after treated with oxytocin or histamine. Results: The contraction frequency, tension and motoricity of isolated rat uterus decreased with water extract and alcohol extract form myrobalan; the contraction frequency of isolated rat uterus significantly reduced with water extract of myrobalan; the water extract of myrobalan could increase the tension, the contraction frequency and the contraction amplitude of isolated rat uterus after the rat was treated with histamine. Conclusion: The extracts (water extract and alcohol extract form myrobalan) can inhibit the spontaneous contraction of isolated rat uterus, and it has the same function after the rat was treated with oxytocin. Water extract of myrobalan can antagonize the contraction of isolated rat uterus after
the rat was treated with histamine.

Key words: myrobalan bark, oxytocin, histamine, excised uterus of rats

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