Abstract:

Objective: To study the efficacy and safety of triple therapy （lansoprazole, clarithromycin tablets, and amoxicillin
capsules）with probiotics in the treatment of helicobacter pylori infection. Methods:118 cases of chronic gastritis or peptic ulcer with any two positive results of rapid urease test, pathological staining, 13C- urease expiratory test were randomly divided into two groups: 60 cases of combined treatment group, lansoprazole clarithromycin and Amoxicillin capsules with 0.35 g of bifidobacterium 0.7 g Po,bid, and 2 h interval taking antibiotics, course 14 d, 58 cases of the control group, lansoprazole clarithromycin and Amoxicillin capsules without Bifidobacterium, course 14 d. Repeat 13C- urea breath test after 4 weeks. Compare the eradication rate and adverse reaction rate of two groups. Results: the eradication rate of treatment group was 80%; the control group the eradication rate was 77.5%, there was no significant difference between the two groups （P>0.05）, but the adverse reaction incidence were statistically
significant different （P <0.05） between treatment group 6.7% and control group 22.4% . Conclusion: Triple therapy with bifidobacterium tablets in the treatment of Hp infection which has less side effect, is worthy of clinical application.

Key words: triple therapy, probiotics, Helicobacter pylori