J4 ›› 2014, Vol. 13 ›› Issue (2): 55-57.

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Anti mutagenicity of Extracts of the Yunnan Pinecones by Vicia-Micronucleus Test

  

  1. （1. Pre-clinical College, Dali University, Dali, Yunnan 671000, China；2. College of Agriculture and Biology Science, Dali University, Dali, Yunnan 671003, China；3. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China；4. College of Public Health, Dali University, Dali, Yunnan 671000, China；5. School of Public Health, University of South China, Hengyang, Hunan 421001, China）
  • Received:2013-09-26 Revised:2013-12-19 Online:2014-02-15 Published:2014-02-15

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Abstract:

Objective: To investigate the anti- mutagenicity of the extracts of Yunnan pincones. Methods: Horsebeans from
Dengchuan village and Wanqiao village were divided into 4 groups randomly. After the pretreatment, vicia-micronucleus test was applied to explore the anti- mutagenicity of the extracts of pinecones. Results: The extract I of Yunnan pinecone showed 50% inhibition on the Dengchuan fava beans-induced micronucleus, 62.5% inhibition on cyclophosphamide-induced micronucleus and 50% inhibition on Wanqiao fava beans root-induced micronucleus. Conclusion: Yunnan pinecone extract effectively inhibited viciamicronucleus induced by cyclophosphamide solution and showed anti-mutagenicity. Thus the extracts of pinecones may have positive effect on tumor prevention.

Key words: pinecones extract, anti-mutagenicity, Vica-micronucleus test

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