Abstract:

Objective: To understand the distribution and drug resistance of pathogenic bacteria in blood culture, and provide a
reference basis for clinical treatment of infectious diseases. Methods: Bact/Alert 3D system was used for blood culture, the
identification of bacteria and susceptibility test were performed by VITEK- 2 Compact identification system and the Kirby-Bauer
method; the distribution and drug resistance of pathogenic bacteria were analyzed statistically. Results: 391 strains of pathogenic
bacteria were isolated in 4 758 specimens of blood culture, with the positive rate of 8.22%. Of 391 strains were 197 strains of Gramnegative bacillus, with the highest positive rate of E. coli（131 strains）, followed by Pneumonia klebsiella bacteria（21 strains）and Onion burkholderia bacteria（10 strains）, and 182 strains of Gram-positive coccus, with three highest positive rate of bacteria in order i.e. Staphylococcus epidermidis（53 strains）, Staphylococcus hominis（39 strains）and Staphylococcus aureus（22 strains）. The resistant rates of E. coli to ampicillin, ceftriaxone were 94.92%, 81.36%, 63.49% respectively. The resistant rates of Staphylococcus epidermidis to penicillin G, erythromycin, compound sulfamethoxazole were as high as 95.65%, 75.51%. Conclusion: A variety of pathogenic bacteria in blood culture were found, of which E. coli and Coagulase negative staphylococci were dominant and they had a high drug resistant rate to the common antibiotics. The monitoring of the drug resistance should be strengthened and antibiotics should be reasonably selected based on the result of drug sensitivity test.

Key words: blood culture, pathogenic bacteria, drug resistance