大理大学学报 ›› 2022, Vol. 7 ›› Issue (2): 39-45.

• 基础医学 • 上一篇    下一篇

PARVG基因在肾透明细胞癌患者中的表达及临床意义

王立韬1,2,白 丽1,2*   

  1. (1.大理大学基础医学院,云南大理 671000;2.云南省昆虫生物医药研发重点实验室,云南大理 671000)

  • 收稿日期:2021-10-29 修回日期:2021-11-17 出版日期:2022-02-15 发布日期:2022-03-29
  • 通讯作者: 白丽,教授,博士,E-mail:lbai@dali.edu.cn。
  • 作者简介: 王立韬,硕士研究生,主要从事临床肿瘤学和分子免疫学研究。
  • 基金资助:
     国家自然科学基金项目(81360319);云南省中药饮片产业发展专项资金项目(2019-YG-067)

Expression and Clinical Significance of PARVG Gene in Patients with Renal Clear Cell Carcinoma

Wang Litao1,2, Bai Li1,2*   

  1. (1.Pre-clinical College, Dali, Yunnan 671000, China; 2. Yunnan Key Laboratory of Insect Biomedicine Research and Development, Dali, Yunnan 671000, China)

  • Received:2021-10-29 Revised:2021-11-17 Online:2022-02-15 Published:2022-03-29

摘要: 目的:基于生物信息学方法探讨PARVG基因在肾透明细胞癌(KIRC)中的表达及功能。方法:利用多种在线数据库和软件综合分析PARVG基因在KIRC中的预后价值及其相关的调控机制。结果:PARVG基因在KIRC中的表达水平显著高于癌旁正常组织(P<0.05);PARVG基因表达水平与患者不同的肿瘤分期与分级、种族、年龄等临床病理特征直接相关,且其高表达水平提示患者预后不良(P<0.05);PARVG基因的共表达基因有17个,其生物信息学功能主要富集于细胞质膜的形成及完整性的维持、细胞通讯、信号转导等多个方面。结论:PARVG基因在KIRC患者中呈现高表达,可作为KIRC患者诊断、治疗和预后的潜在靶点。

关键词: font-family:SimSun, ">肾透明细胞癌;font-family:SimSun, ">PARVGfont-family:SimSun, ">基因;生物信息学分析

Abstract:  Objective: To investigate the expression and function of PARVG gene in kidney renal clear cell carcinoma (KIRC) based on bioinformatics. Methods: A variety of online databases and software were used to synthetically analyze the prognostic value of PARVG gene in KIRC and its related regulatory mechanism. Results: The expression level of PARVG gene in KIRC was significantly higher than that in normal tissues adjacent to cancer (P<0.05), and the expression level of PARVG gene was directly related to the clinicopathological features of patients with different tumor stages, grades, ethnicities and ages, and its high expression level suggested a poor prognosis (P<0.05). There are 17 co-expressed genes of PARVG gene, and its bioinformatics function is mainly concentrated on the formation and maintenance of plasma membrane, cell communication, signal transduction and so on. Conclusion: PARVG gene is highly expressed in KIRC patients, which can be used as a potential target for diagnosis, treatment and prognosis of KIRC patients.

Key words:

 , KIRC">; PARVG">; bioinformatics analysis

中图分类号: