大理大学学报 ›› 2023, Vol. 8 ›› Issue (2): 42-45.

• 临床医学 • 上一篇    下一篇

格雷夫斯病患者血清颗粒蛋白前体表达情况及其与IL-17、IL-10相关性分析

宋秋玲,代 娇*   

  1. (曲靖医学高等专科学校,云南曲靖 655000)

  • 收稿日期:2021-11-01 修回日期:2022-09-05 出版日期:2023-02-15 发布日期:2023-03-02
  • 通讯作者: 代娇,实验师,E-mail:qjyzdaijoy@163.com。
  • 作者简介:宋秋玲,讲师,主要从事微生物和自身免疫性相关疾病诊治研究。

The Expression of Serum Progranulin in Patients with Graves Disease and Its Correlation with IL-17 and IL-10

Song Qiuling, Dai Jiao*   

  1. (Qujing Medical College, Qujing, Yunnan 655000, China)

  • Received:2021-11-01 Revised:2022-09-05 Online:2023-02-15 Published:2023-03-02

摘要: 目的:探究格雷夫斯病(GD)患者血清颗粒蛋白前体(PGRN)的表达情况及其与白细胞介素-17(IL-17)和白细胞介素-10(IL-10)的相关性。方法:采用酶联免疫吸附试验测定GD患者和同期健康体检者血清PGRN、IL-17和IL-10水平,并用Spearman相关性分析法分析PGRN与IL-17、IL-10的相关性。结果:与健康体检者比较,GD患者血清PGRN、IL-17水平显著升高,IL-10水平显著降低,差异有统计学意义(P<0.01);Spearman相关性分析结果显示,GD患者血清PGRN水平与IL-17水平呈显著正相关,与IL-10水平呈显著负相关;接受131I治疗的GD患者,与治疗前相比,血清PGRN、IL-17水平显著降低,IL-10水平显著升高,差异有统计学意义(P<0.01)。结论:GD患者血清PGRN水平升高,且与IL-17、IL-10水平显著相关,提示其可能参与了疾病的发生、发展过程。

关键词: font-family:宋体, ">颗粒蛋白前体, 格雷夫斯病, 白细胞介素font-family:", ">-17font-family:宋体, ">, 白细胞介素font-family:", ">-10

Abstract: Objective: To investigate the expression of serum progranulin(PGRN) in patients with Graves disease(GD) and its correlation with interleukin-17(IL-17) and interleukin-10(IL-10). Methods: The serum PGRN, IL-17 and IL-10 levels of GD patients and healthy subjects were measured by enzyme-linked immunosorbent assay, and the correlation between PGRN and IL-17 and IL-10 was analyzed by Spearman correlation analysis. Results: Compared with the healthy subjects, the serum levels of PGRN and IL-17 in GD patients were significantly higher, while the level of IL-10 was significantly lower, with statistically significance (P<0.01). The results of Spearman correlation analysis showed that serum PGRN levels in GD patients were significantly positively correlated with IL-17 levels, and negatively correlated with IL-10 levels. Compared with before treatment, the levels of PGRN and IL-17 in serum of GD patients treated with 131I decreased significantly, while the level of IL-10 increased significantly, with statistically significance(P<0.01). Conclusion: The level of serum PGRN in GD patients is elevated, and it is significantly correlated with the levels of IL-17 and IL-10, suggesting that it may be involved in the occurrence and development of the disease.

Key words: font-family:Times New Roman, ">progranulinfont-family:Times New Roman, ">, font-family:Times New Roman, "> Graves diseasefont-family:Times New Roman, ">, font-family:Times New Roman, "> interleukin-17font-family:Times New Roman, ">, font-family:Times New Roman, "> interleukin-10

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