J4 ›› 2012, Vol. 11 ›› Issue (3): 9-11.

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Chemical Constituents of Root of Isodon adenantha

Objective: To explore the chemical constituents of root of Isodon adenantha. Methods: Compounds were separated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral analysis and chemical evidences. Results: Six compounds were obtained from ethyl acetate fraction of the extract of root of I. adenantha and were identified as 8（17）, 13-ent-labda-dien-15→16-lactone-19-oic acid（1 ）, adenanthin（ 2）, ursolic acid（3 ）, β-sitosterol（ 4）, stigmast-5,22-dien-3β,7α-diol （5）, and 5,8-Epidioxy-5α,8α-ergosta-6,22E- dien-3β-ol （6 ）. Conclusion: Compounds 1~6 were isolated from the root of I. adenantha for the first time. while the compounds 5 and 6 were firstly obtained from this plant.   

  1. College of Pharmacy and Chemistry, Dali University, Dali Yunnan 671000, China
  • Received:2012-01-04 Revised:2012-01-19 Online:2012-03-15 Published:2012-03-15

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Abstract:

Objective: To explore the chemical constituents of root of Isodon adenantha. Methods: Compounds were separated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral analysis and chemical evidences. Results: Six compounds were obtained from ethyl acetate fraction of the extract of root of I. adenantha and were identified as 8（17）, 13-ent-labda-dien-15→16-lactone-19-oic acid（1 ）, adenanthin（ 2）, ursolic acid（3 ）, β-sitosterol（ 4）, stigmast-5,22-dien-3β,7α-diol （5）, and 5,8-Epidioxy-5α,8α-ergosta-6,22E- dien-3β-ol （6 ）. Conclusion: Compounds 1~6 were isolated from the root of I. adenantha for the first time. while the compounds 5 and 6 were firstly obtained from this plant.

Key words: Isodon adenantha, root, terpenoids, steroids

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