Evaluation of the Drug Utilization of Young Patients with Cerebral Ischemic Stroke in a Hospital in Dali City by DUR and DUE

Abstract

Abstract:

〔Abstract〕 Objective： To evaluate the drug utilization and rationality of young patients with cerebral ischemic stroke in the First Affiliated Hospital of Dali University from 2018 to 2020. Methods： Drug utilization review（DUR） and drug utilization evaluation（DUE） were used to evaluate the type， frequency and rationality of drugs used by patients. Results： 61 drugs in 13 categories were applied in the treatment of 75 patients， including 48 western drugs and 13 traditional Chinese medicine injections， among which the proportion of lipid-regulating drugs was the highest， reaching 98.7%. DUR results showed that the drug utilization index（DUI） of 11 drugs was greater than 1， the DUI of 24 drugs was 1， and the DUI of 26 drugs was less than 1. Western drugs with DUI greater than 1 were mainly acid inhibitor and antihypertensive drugs， while drugs with DUI less than 1 were of a wide variety， mostly caused by dose reduction in combination drugs. DUE results showed that the monitoring rate of drug-related laboratory test indicators was low， and the main adverse reactions were gastrointestinal reactions. After drug treatment， the clinical symptoms of 74 patients were improved. Conclusion： The selection of drugs for young patients with cerebral ischemic stroke in this hospital is reasonable， but it is necessary to strengthen the management of acid inhibitor and antihypertensive drugs， and strengthen the monitoring of related laboratory indicators and adverse reactions during treatment.

Key words:

"> font-size:10.5pt, ">cerebral ischemic stroke, youth, drug utilization review, drug utilization evaluation, adverse reactions

CLC Number:

Wu Rongshuang, Ma Ancui, Shen Lei.

Evaluation of the Drug Utilization of Young Patients with Cerebral Ischemic Stroke in a Hospital in Dali City by DUR and DUE [J]. Journal of Dali University, 2022, 7(10): 15-21.

References

〔1〕王陇德，彭斌，张鸿祺，等. 《中国脑卒中防治报告2020》概要〔J〕.中国脑血管病杂志，2022，19（2）：136-144.

〔2〕 BÉJOT Y， BAILLY H， DURIER J， et al. Epidemiology of Stroke in Europe and Trends for the 21st Century〔J〕. Presse Méd， 2016， 45（12 Pt 2）： e391-e398.

〔3〕郑杨，杨亮蕊，刘全义. 应用DUR和DUE法评价泌尿外科患者抗菌药使用情况〔J〕. 中国当代医药，2019，26（33）：17-20.

〔4〕沈斌，蒋利亚，张小平，等. 药物利用评价法和药物利用评估法在慢性乙型肝炎药物治疗中的应用研究〔J〕. 中国临床药理学与治疗学，2016，21（12）：1419-1424.

〔5〕石庆平，孙利华，丁永为. 采用DUR和DUE方法评价本医院恶性淋巴瘤患者的用药情况〔J〕. 中国药房，2006，17（21）：1630-1632.

〔6〕付虹，谭喜莹，戎有和. 缺血性脑卒中患者的治疗药物评价〔J〕. 实用药物与临床，2019，22（1）：69-74.

〔7〕国家药典委员会. 中华人民共和国药典临床用药须知：中药成方制剂卷（2015年版）〔M〕.北京：中国医药科技出版社，2017.

〔8〕国家药典委员会.中华人民共和国药典临床用药须知：化学药和生物制品卷（2015年版）〔M〕.北京：中国医药科技出版社，2017.

〔9〕中华医学会，中华医学会杂志社，中华医学会全科医学分会，等.缺血性卒中基层诊疗指南（实践版·2021）〔J〕.中华全科医师杂志，2021，20（9）：947-958.

〔10〕刘钢，李毅，高晓刚，等. 脑卒中相关性肺炎与H2-受体拮抗剂或质子泵抑制剂应用的关系〔J〕. 中国老年学杂志，2018，38（3）：597-599.

〔11〕中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组，中国医学科学院北京协和医院神经科，等. 中国急性缺血性脑卒中诊治指南2018〔J〕.中华神经科杂志，2018，51（9）：666-682.

〔12〕 ZHANG N， LIU G F， ZHANG G H， et al. A Risk Score Based on Get with the Guidelines-Stroke Program Data Works in Patients with Acute Ischemic Stroke in China 〔J〕. Stroke， 2012， 43（11）： 3108-3109.

〔13〕耿春生，杨伟民，张丽，等. 青年急性脑梗死患者的危险因素及病因分型分析〔J〕. 中国实用神经疾病杂志，2020，23（4）：277-281.

〔14〕邹兆鹏，范锦闳，何治. 同型半胱氨酸对缺血性脑卒中的影响〔J〕. 生命的化学，2020，40（3）：351-357.

〔15〕林磊. 血清同型半胱氨酸水平与中青年脑梗死后抑郁的相关性研究〔J〕. 医学信息，2021，34（2）：127-128.

〔16〕陈红兵，洪华，刘刚，等. 青年缺血性卒中或短暂性脑缺血发作患者卒中复发风险及其预测因子〔J〕. 中国脑血管病杂志，2015，12（9）：462-467.

〔17〕刘琛，沈芊，李晓玲，等. 首都医科大学宣武医院2011年老年脑梗死住院患者的药物利用研究〔J〕. 中国循证医学杂志，2015，15（10）：1132-1136.

〔18〕曹晓岚，郭闫葵，耿昌，等. 缺血性中风住院患者用药情况的回顾性调查〔J〕. 中西医结合心脑血管病杂志，2014，12（5）：529-531.

〔19〕赵宪荣，武夏明，刘伦，等. 山东省8家医院脑梗死住院患者用药分析〔J〕. 中国药房，2005，16（18）：1397-1399.

〔20〕李玉媚，宁剑，王柳萍，等. 150例急性脑梗死住院患者用药特点分析〔J〕. 中国药房，2015，26（2）：156-159.

〔21〕于泓，李云革，李佳艳. 叶酸、维生素B6和甲钴胺治疗伴高同型半胱氨酸血症青年脑卒中的临床效果研究〔J〕. 神经损伤与功能重建，2019，14（7）：367-368.

〔22〕 CHANG C Y， CHEN J Y， WU M H， et al. Therapeutic Treatment with Vitamin C Reduces Focal Cerebral Ischemia-Induced Brain Infarction in Rats by Attenuating Disruptions of Blood Brain Barrier and Cerebral Neuronal Apoptosis〔J〕. Free Radic Biol Med， 2020， 155： 29-36.

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