A Preliminary Study on the Correlation
between Obesity and Oxidative Stress in College Students

Abstract

Abstract:

Objective： To explore the correlation between obesity and oxidative stress among college students， and to provide research programs and techniques for the development of diagnostic criteria for oxidative inflammation. Methods： 80 students from Dali University were randomly selected as the subjects of study， and urine samples were taken during physical examination； the urine 8-hydroxy-2'-deoxyguanosine （8-OHdG） content was determined by enzyme linked immunosorbent assay （ELISA）. And the body mass index （BMI） is calculated based on the height and body mass data； SPSS 17.0 software were used to perform linear correlation analysis and one-way analysis of variance. Results： BMI value was positively correlated with urine 8-OHdG content， among which rboys=0.332， rgirls=0.338， and rtotal=0.341； obese and overweight people had higher urine 8-OHdG levels than those of normal body mass. Conclusion： Obesity and oxidative stress/oxidative inflammation in college students are downstream events of excess energy intake. There is a statistical correlation between the two， but not causal relationship. There is a quantitative "mirror relationship" between them which provides the possibility to use the diagnostic criteria of obesity to explore the diagnostic criteria of oxidative inflammation.

Key words: font-family:SimSun, ">college studentsfont-family:SimSun, ">；font-family:SimSun, "> obesityfont-family:SimSun, ">；font-family:SimSun, "> oxidative stressfont-family:SimSun, ">；font-family:SimSun, "> 8-hydroxy-2'-deoxyguanosinefont-family:SimSun, ">；font-family:SimSun, "> body mass index

CLC Number:

Zhang Qian, She Rong, Yang Xiaoyan, Yin Chunlei, Li Lijuan.

A Preliminary Study on the Correlation between Obesity and Oxidative Stress in College Students [J]. Journal of Dali University, 2022, 7(2): 76-81.

References

〔1〕 GBD 2017 DIET COLLABORATORS. Health Effects of Dietary Risks in 195 Countries，1990-2017：A Systematic Analysis for the Global Burden of Disease Study 2017〔J〕. Lancet， 2019， 393（10184）： 1958-1972.

〔2〕 KOPP W. How Western Diet and Lifestyle Drive the Pandemic of Obesity and Civilization Diseases〔J〕. Diabe-tes Metab Syndr Obes：Targets Ther，2019，12：2221-2236.

〔3〕中华人民共和国国家卫生健康委员会.中国居民营养与慢性病状况报告（2020年）〔EB/OL〕. （2020-12-23）〔2021-03-15〕．http：//www.nhc.gov.cn/xcs/s3574/202012/bc4379ddf4324e7f86f05d31cc1c4982.shtml.

〔4〕 DANDONA P， GHANIM H， CHAUDHURI A， et al. Macronutrient Intake Induces Oxidative and Inflammatory Stress： Potential Relevance to Atherosclerosis and Insulin Resistance〔J〕. Exp Mol Med， 2010， 42（4）： 245-253.

〔5〕 SIES H. Oxidative Stress： A Concept in Redox Biology and Medicine〔J〕. Redox Biol， 2015， 4： 180-183.

〔6〕 WU Y， LI K， ZUO H X， et al. Primary Neuronal-Astrocytic Co-Culture Platform for Neurotoxicity Assess-ment of Di-（2-Ethylhexyl） Phthalate〔J〕. J Environ Sci （China）， 2014， 26（5）： 1145-1153.

〔7〕施志慧，史训龙，朱海燕，等.病毒感染与氧化应激的关系〔J〕.复旦学报（医学版），2012，39（1）：80-85.

〔8〕于晨，董超然，张照辉，等.8-羟基脱氧鸟嘌呤作为DNA氧化损伤标志物的研究现状〔J〕.中国临床药理学杂志，2017，33（13）：1267-1270.

〔9〕 HOPF N B， BOURGKARD E， DEMANGE V， et al. Early Effect Markers and Exposure Determinants of Metalworking Fluids among Metal Industry Workers： Protocol for a Field Study〔J〕. JMIR Res Protoc， 2019， 8（8）： e13744.

〔10〕 BERGAMASCHI E， POLAND C， GUSEVA CANU I， et al. The Role of Biological Monitoring in Nano-Safety〔J〕. Nano Today， 2015， 10（3）： 274-277.

〔11〕 BARREGARD L， M?覫LLER P， HENRIKSEN T， et al. Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7， 8-Dihydro-2'-Deoxy-guanosine〔J〕. Antioxid Redox Signal， 2013， 18（18）： 2377-2391.

〔12〕 ZANOLIN M E， GIRARDI P， DEGAN P， et al. Measurement of a Urinary Marker （8-Hydroxydeoxy-Guanosine， 8-OHdG） of DNA Oxidative Stress in Epide-miological Surveys： A Pilot Study〔J〕. Int J Biol Mark-ers， 2015， 30（3）： 341-345.

〔13〕 LUSHCHAK V I. Free Radicals， Reactive Oxygen Species， Oxidative Stress and Its Classification〔J〕. Chem Biol Interact， 2014， 224： 164-175.

〔14〕 SHIGENAGA M K， GIMENO C J， AMES B N. Urinary 8-Hydroxy-2'-Deoxyguanosine as a Biological Marker of in vivo Oxidative DNA Damage〔J〕. Proc Natl Acad Sci USA， 1989， 86（24）： 9697-9701.

〔15〕 KASAI H. Analysis of a Form of Oxidative DNA Damage， 8-Hydroxy-2'-Deoxyguanosine， as a Marker of Cellular Oxidative Stress during Carcinogenesis〔J〕. Mutat Res，1997， 387（3）： 147-163.

〔16〕 BECKMAN K B， AMES B N. Oxidative Decay of DNA〔J〕. J Biol Chem， 1997， 272（32）： 19633-19636.

〔17〕 KASAI H， HAYAMI H， YAMAIZUMI Z， et al. Detec-tion and Identification of Mutagens and Carcinogens as Their Adducts with Guanosine Derivatives〔J〕. Nucleic Acids Res， 1984， 12（4）： 2127-2136.

〔18〕 MARTINEZ-MORAL M P， KANNAN K. How Stable Is Oxidative Stress Level? An Observational Study of Intra- and Inter-Individual Variability in Urinary Oxidative Stress Biomarkers of DNA， Proteins， and Lipids in Healthy Individuals〔J〕. Environ Int，2019，123：382-389.

〔19〕张倩，尹春蕾，李丽娟.大理大学不同海拔生源地学生体质状况分析〔J〕.大理大学学报，2021，6（12）：74-79.

〔20〕 ZALEWSKA A， KOSSAKOWSKA A， TARANTA-JAN-USZ K， et al. Dysfunction of Salivary Glands， Disturb-ances in Salivary Antioxidants and Increased Oxidative Damage in Saliva of Overweight and Obese Adole-

scents〔J〕. J Clin Med，2020，9（2）：E548.

〔21〕肖文，杨旭.中国大健康面临的关键问题：能量摄入过剩和氧化炎症〔J〕.中国中药杂志，2022，47（4）：853-861.

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A Preliminary Study on the Correlation between Obesity and Oxidative Stress in College Students

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