Analysis of Clinical Significance of Cytokine and Acute Protein Detection in Patients with Mycobacterium Infectious Lung Disease

Abstract

Abstract:

Objective： To study the clinical significance of serum cytokine and acute protein detection in patients with mycobacterium infectious lung disease. Methods： The levels of interleukin（ＩＬ）-1， interleukin-2 receptor（IL-2R）， IL-6， IL-8， IL-10， tumor necrosis factor-α（TNF-α）， α2-macroglobulin（AMG）， complement C1q and B factors in serum of the target population were detected by enzyme-linked immunosorbent assay and immunonephelometry. Results： Compared with healthy subjects （control group）， the levels of IL-2R and TNF-α in the serum of pulmonary tuberculosis patients （MTB group） and non-tuberculous mycobacterium lung disease patients （NTM group） were significantly increased， while the levels of AMG was significantly decreased， and the levels of C1q and B factors were significantly increased， with statistical significance （P<0.05）. However， there was no significant difference in the levels of cytokine and acute protein between the MTB group and the NTM group（P>0.05）. Conclusion： The levels of TNF-α were significantly increased in the serum of patients in both the MTB and NTM groups， which can be used to understand the pathogenesis of these two lung diseases. The increased levels of IL-2R were associated with disease activity. The decreased levels of AMG can serve as a biomarker for immune system dysregulation.

Key words:

pulmonary tuberculosis, nontuberculous mycobacteria lung disease, cytokine, acute protein

CLC Number:

R378.911 ','1');return false;" target="_blank">
R378.911

Li Xiangfang, Wang Xuan, Ding Shoupeng, Ma Fengqian, Wu Lixian.

Analysis of Clinical Significance of Cytokine and Acute Protein Detection in Patients with Mycobacterium Infectious Lung Disease [J]. Journal of Dali University, 2023, 8(10): 68-71.

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