Journal of Dali University ›› 2023, Vol. 8 ›› Issue (2): 42-45.

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The Expression of Serum Progranulin in Patients with Graves Disease and Its Correlation with IL-17 and IL-10

Song Qiuling, Dai Jiao*   

  1. (Qujing Medical College, Qujing, Yunnan 655000, China)

  • Received:2021-11-01 Revised:2022-09-05 Online:2023-02-15 Published:2023-03-02

Abstract: Objective: To investigate the expression of serum progranulin(PGRN) in patients with Graves disease(GD) and its correlation with interleukin-17(IL-17) and interleukin-10(IL-10). Methods: The serum PGRN, IL-17 and IL-10 levels of GD patients and healthy subjects were measured by enzyme-linked immunosorbent assay, and the correlation between PGRN and IL-17 and IL-10 was analyzed by Spearman correlation analysis. Results: Compared with the healthy subjects, the serum levels of PGRN and IL-17 in GD patients were significantly higher, while the level of IL-10 was significantly lower, with statistically significance (P<0.01). The results of Spearman correlation analysis showed that serum PGRN levels in GD patients were significantly positively correlated with IL-17 levels, and negatively correlated with IL-10 levels. Compared with before treatment, the levels of PGRN and IL-17 in serum of GD patients treated with 131I decreased significantly, while the level of IL-10 increased significantly, with statistically significance(P<0.01). Conclusion: The level of serum PGRN in GD patients is elevated, and it is significantly correlated with the levels of IL-17 and IL-10, suggesting that it may be involved in the occurrence and development of the disease.

Key words: font-family:Times New Roman, ">progranulinfont-family:Times New Roman, ">, font-family:Times New Roman, "> Graves diseasefont-family:Times New Roman, ">, font-family:Times New Roman, "> interleukin-17font-family:Times New Roman, ">, font-family:Times New Roman, "> interleukin-10

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