Journal of Dali University ›› 2022, Vol. 7 ›› Issue (2): 39-45.

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Expression and Clinical Significance of PARVG Gene in Patients with Renal Clear Cell Carcinoma

Wang Litao1,2, Bai Li1,2*   

  1. (1.Pre-clinical College, Dali, Yunnan 671000, China; 2. Yunnan Key Laboratory of Insect Biomedicine Research and Development, Dali, Yunnan 671000, China)

  • Received:2021-10-29 Revised:2021-11-17 Online:2022-02-15 Published:2022-03-29

Abstract:  Objective: To investigate the expression and function of PARVG gene in kidney renal clear cell carcinoma (KIRC) based on bioinformatics. Methods: A variety of online databases and software were used to synthetically analyze the prognostic value of PARVG gene in KIRC and its related regulatory mechanism. Results: The expression level of PARVG gene in KIRC was significantly higher than that in normal tissues adjacent to cancer (P<0.05), and the expression level of PARVG gene was directly related to the clinicopathological features of patients with different tumor stages, grades, ethnicities and ages, and its high expression level suggested a poor prognosis (P<0.05). There are 17 co-expressed genes of PARVG gene, and its bioinformatics function is mainly concentrated on the formation and maintenance of plasma membrane, cell communication, signal transduction and so on. Conclusion: PARVG gene is highly expressed in KIRC patients, which can be used as a potential target for diagnosis, treatment and prognosis of KIRC patients.

Key words:

 , KIRC">; PARVG">; bioinformatics analysis

CLC Number: