Journal of Dali University ›› 2022, Vol. 7 ›› Issue (2): 51-56.

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Efficacy Analysis of Two Methods in the Treatment of Severe Non-Proliferative Diabetic Retinopathy

Liu Teng1, Cheng Fei1, Yang Pinjiao1,2, Jia Yunqin2, Han Peiyan2, Tao Tao2, Duan Zhiguang2*   

  1. (1.Clinical College, Dali University, Dali, Yunnan 671000, China; 2. Department of Ophthalmology, The People's Hospital of Dali Bai Autonomous Prefecture, Dali, Yunnan 671000, China)

  • Received:2020-10-22 Revised:2021-04-29 Online:2022-02-15 Published:2022-03-29

Abstract:

Objective: To evaluate the clinical efficacy of pure panretinal photocoagulation(PRP) and intravitreal injection of Conbercept combined with PRP in the treatment of severe non-proliferative diabetic retinopathy (NPDR). Methods: 59 patients (84 eyes) with severe NPDR were randomly divided into a combination group of 33 cases(48 eyes) and a control group of 26 cases (36 eyes). The combination group received intravitreal injection of Conbercept combined with PRP, while the control group received PRP. The best corrected visual acuity(BCVA), central foveal thickness(CFT) and quality of life score between the two groups of patients after treatment were analyzed and compared. Results: The BCVA and CFT of the two groups of patients after treatment were better than those before treatment, and the differences were statistically significant (P<0.05); after treatment, the BCVA and CFT of the combined group were better than those of the control group, and the differences were statistically significant(P<0.05); the laser energy, number of spots and energy density used in the treatment of the combination group were lower than those of the control group, and the differences were statistically significant(P<0.05); the quality of life score of patients in the combination group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion: Conbercept intravitreal injection combined with PRP to treat NPDR can use relatively less laser energy to inhibit the growth of retinal neovascularization, promote the absorption of macular edema and improve the visual function of patients in a short time, so its therapeutic effect is significantly better than pure PRP treatment.

Key words: font-family:SimSun, ">non-proliferative diabetic retinopathyfont-family:SimSun, ">;font-family:SimSun, "> Conberceptfont-family:SimSun, ">;font-family:SimSun, "> panretinal photocoagulation

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