J4 ›› 2012, Vol. 11 ›› Issue (12): 10-12.
目的:探讨PPARα在器官移植中的作用。方法:C57BL/6J经口给予非诺贝特或者Wy14643,连续7 d,取脾脏,同时取
BALB/c小鼠的脾脏,分离脾细胞进行混合淋巴细胞反应。结果:经过非诺贝特或者Wy14643处理的小鼠,其脾细胞在混合淋巴细
胞反应中表现为无应答。结论:非诺贝特或者Wy14643激活的PPARα具有抑制混合淋巴细胞反应的作用。
Objective: To investigate the effect of PPARα on organ transplantation on mice model. Methods: Fenofibrate, Wy14643,
or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J, spleen from C57BL/6J or BALB/c
was collected and splenocyte was isolated. Mixed lymphocyte reaction (MLR)was carried out. Results: The splenocyte was no
response in MLR from the mice treated with fenofibrate, or Wy14643. Conclusion: PPARα could be activated by fenofibrate, or
Wy14643, could inhibit MLR.