J4 ›› 2012, Vol. 11 ›› Issue (12): 4-5.

• 基础医学 • 上一篇    下一篇

慈姑多糖降血糖的生物活性研究

目的:考察慈姑多糖对四氧嘧啶性糖尿病模型小鼠血糖的影响。方法:采用皮下一次性注射190 mg/kg四氧嘧啶致实验
性糖尿病小鼠,观察慈姑多糖不同剂量(0.75 g/kg,0.375 g/kg)对糖尿病小鼠空腹血糖的影响。结果:慈姑多糖高、低剂量组能显
著性降低血糖水平(P<0.05)。结论:慈姑多糖具有一定的降血糖作用。   

  1. 大理学院基础医学院,云南大理 671000
  • 收稿日期:2012-07-17 修回日期:2012-09-14 出版日期:2012-12-15 发布日期:2012-12-15
  • 作者简介:罗永会,实验师,主要从事生物化学实验教学和多糖研究.
  • 基金资助:

    大理学院青年科学基金资助项目(KYQN2009-44)

Research on Hypoglycemic Effect of the Sagittaria Sagittifolin Polysaccharide

Objective: To observe the hypoglycemic effect of polysaccharide from Sagittaria sagittifolin in alloxan-induced diabetic
mice. Methods: The diabetic model mice were established by intra-abdominal injection of 190 mg/kg alloxan, the hypoglycemic
effects of Sagittaria sagittifolin polysaccharide in 0.75 g/kg and 0.375 g/kg were examined. Results: Sagittaria sagittifolin
polysaccharide in two doses could both significantly decrease the blood glucose in diabetic mice (P<0.05). Conclusion: Sagittaria
sagittifolin polysaccharide showed certain hypoglycemic effect on diabetic mice model.   

  1. Pre-clinical College,Dali University, Dali, Yunnan 671000, China
  • Received:2012-07-17 Revised:2012-09-14 Online:2012-12-15 Published:2012-12-15

摘要:

目的:考察慈姑多糖对四氧嘧啶性糖尿病模型小鼠血糖的影响。方法:采用皮下一次性注射190 mg/kg四氧嘧啶致实验
性糖尿病小鼠,观察慈姑多糖不同剂量(0.75 g/kg,0.375 g/kg)对糖尿病小鼠空腹血糖的影响。结果:慈姑多糖高、低剂量组能显
著性降低血糖水平(P<0.05)。结论:慈姑多糖具有一定的降血糖作用。

关键词: 慈姑多糖, 糖尿病, 四氧嘧啶, 降血糖

Abstract:

Objective: To observe the hypoglycemic effect of polysaccharide from Sagittaria sagittifolin in alloxan-induced diabetic
mice. Methods: The diabetic model mice were established by intra-abdominal injection of 190 mg/kg alloxan, the hypoglycemic
effects of Sagittaria sagittifolin polysaccharide in 0.75 g/kg and 0.375 g/kg were examined. Results: Sagittaria sagittifolin
polysaccharide in two doses could both significantly decrease the blood glucose in diabetic mice (P<0.05). Conclusion: Sagittaria
sagittifolin polysaccharide showed certain hypoglycemic effect on diabetic mice model.

Key words: Sagittaria sagittifolin polysaccharide, diabetic mellitus, alloxan, hypoglycemic effect

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