Survivin和OPN在不同宫颈病变组织中的表达及相关研究

J4 ›› 2015, Vol. 14 ›› Issue (8): 49-52.

Survivin和OPN在不同宫颈病变组织中的表达及相关研究

（1.大理学院，云南大理671000；2.保山中医药高等专科学校，云南保山678000）

出版日期:2015-08-15 发布日期:2015-08-15
作者简介:王艳书，讲师，主要从事临床护理学研究.
基金资助:
云南省教育厅科研基金一般项目（2014Y400）

Expressions and Related Studies of Survivin and OPN in Different Cervical Lesions

（1. Dali University, Dali, Yunnan 671000, China; 2.Baoshan College of Traditional Chinese Medicine, Baoshan,
Yunnan 678000, China）

Online:2015-08-15 Published:2015-08-15

摘要/Abstract

摘要：

目的：探讨Survivin、OPN在慢性宫颈炎、宫颈上皮内瘤（CIN）、宫颈鳞癌组织中的表达情况。方法：采用免疫组织化学
SP法检测Survivin、OPN在10例慢性宫颈炎、20例宫颈上皮内瘤变Ⅲ期（CINⅢ）和50例宫颈鳞癌组织中的表达情况。结果：
Survivin和OPN在慢性宫颈炎、CINⅢ、宫颈鳞癌中的表达阳性率均随病变严重程度逐级增强，3组比较差异均有统计学意义
（P <0.05）。Survivin的表达阳性率与宫颈鳞癌的临床分期、病理分级有关（P <0.05），与年龄、有无淋巴结转移无关（P >0.05）；
Survivin的表达阳性率与宫颈鳞癌的临床分期、有无淋巴结转移有关（P <0.05），与年龄、病理分级无关（P >0.05）。结论：Sur?
vivin+OPN的联合检测有可能作为宫颈鳞癌的早期诊断、病情监测和预后判断的指标。

关键词: Survivin, OPN, 免疫组化, 慢性宫颈炎, 宫颈上皮内瘤, 宫颈鳞癌

Abstract:

Objective: To discuss the expressions of Survivin and OPN in the tissues of chronic cervitis, cervical intraepithelial
neoplasia（CIN）and cervical squamous carcinoma. Methods: Immunohistochemical SP method was applied to detect the expressions
of Survivin and OPN in 10 cases of chronic cervicitis, 20 cases of CIN and 50 cases of cervical cancer. Results: The expression
positive rate of Survivin and OPN in chronic cervicitis、CINⅢ、cervical squamous carcinomas increased with the lesion severity level
enhancement，three groups of comparative differences are statistically significant（P＜0.05）. The expression positive rate of Survivin
in cervical squamous carcinomas was associated with clinical stages and pathologic stage（P <0.05）, but has nothing to do with age and
lymph nodes metastasis（P >0.05）. The expression positive rate of OPN in cervical squamous carcinomas was associated with clinical
stages and lymph node metastasis（P < 0.05）, but has nothing to do with age and pathologic stage（P > 0.05）. Conclusion: The joint
detection of Survivin and OPN may serve as the index for early diagnosis, condition monitoring and prognosis judgment of cervical
squamous carcinomas.

Key words: Survivin, OPN, immunohistochemical, chronic cervicitis, CIN, cervical squamous carcinomas

中图分类号:

R737.33

王艳书，鲁静，李海燕. Survivin和OPN在不同宫颈病变组织中的表达及相关研究[J]. J4, 2015, 14(8): 49-52.

Wang Yanshu, Lu Jing, Li Haiyan. Expressions and Related Studies of Survivin and OPN in Different Cervical Lesions[J]. J4, 2015, 14(8): 49-52.

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[2]	邵宇，谭云波. 脾窦岸细胞血管瘤1例并文献复习[J]. J4, 2016, 1(4): 50-51.
[3]	蒋剑, 李永萍, 潘云, 李正金, 王红霞. 白血病G6PD蛋白表达的研究[J]. J4, 2011, 10(2): 27-29.
[4]	傅妹伢, 申元英, 罗昊翔, 艾志琼, 张态. 不同修复方法对猪肝脏免疫组化结果的影响[J]. J4, 2010, 9(2): 19-21.