细胞信号通路影响肝纤维化的研究进展

›› 2017, Vol. 2 ›› Issue (2): 46-50.

细胞信号通路影响肝纤维化的研究进展

（大理大学基础医学院，云南大理671000）

收稿日期:2015-12-04 修回日期:2016-05-26 出版日期:2017-02-15 发布日期:2017-02-15
作者简介:杨开明，教授，主要从事细胞信号转导相关研究.

Research on Progress of the Influence of Cell Signaling Pathway on Hepatic Fibrosis

（Pre-clinical College, Dali University, Dali, Yunnan 671000, China）

Received:2015-12-04 Revised:2016-05-26 Online:2017-02-15 Published:2017-02-15

摘要/Abstract

摘要：

目的：了解肝纤维化发生、发展过程中细胞信号通路的作用及机制。方法：复习文献，对近年来有关影响肝纤维化细胞
信号通路的调控作用及机制进行综述。结果：肝纤维化是慢性肝损害产生的一种肝组织自身病理性修复反应，而转化生长因
子-β，血小板衍生生长因子，刺猬信号，Wnt信号，JAK-STAT信号，Notch信号等多条细胞信号通路参与了肝纤维化的发生及
发展过程。结论：肝纤维化是刺猬信号、Wnt信号等多条细胞信号通路和一系列细胞信息分子共同作用的结果。

关键词: 肝纤维化, Wnt信号通路, Hedgehog信号通路, 肝星状细胞

Abstract:

Objective: To investigate the role and mechanism of cell signaling pathway in the occurrence and development of hepatic
fibrosis. Methods: The literature about the regulation of cell signaling pathway and its mechanism in recent years were reviewed.
Results: Hepatic fibrosis is a pathological repair reaction to the chronic liver damage. Cell signaling pathways like TGF-β, PDGF,
hedgehog signaling, Wnt signaling, JAK-STAT and Notch signal participated in the occurrence and development of hepatic fibrosis.
Conclusion: Hepatic fibrosis is the result of a series of cell signaling pathways: hedgehog signal, Wnt signal and a series of cell
information molecules.

Key words: hepatic fibrosis, Wnt signaling, Hedgehog signaling, hepatic satellite cells

中图分类号:

R575

杨开明，蒋文娟，成家茂. 细胞信号通路影响肝纤维化的研究进展[J]. , 2017, 2(2): 46-50.

Yang Kaiming, Jiang Wenjuan, Cheng Jiamao. Research on Progress of the Influence of Cell Signaling Pathway on Hepatic Fibrosis[J]. , 2017, 2(2): 46-50.

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