内皮型一氧化氮合成酶基因rs1799983多态与血压的关系

›› 2017, Vol. 2 ›› Issue (8): 23-27.

内皮型一氧化氮合成酶基因rs1799983多态与血压的关系

（大理大学第一附属医院，云南大理671000）

收稿日期:2016-12-19 修回日期:2017-04-18 出版日期:2017-08-15 发布日期:2017-08-15
作者简介:刘洋，硕士研究生，主要从事心血管流行病学研究.
基金资助:
国家自然科学基金资助项目（30960137；81460084；81660072）；大理大学博士启动基金资助项目（2014-21）；
云南省中青年学术技术带头人后备人才项目（2015HB056）；云南省医学学科带头人培养资助项目（D-201672）

The Relationship between Endothelial Nitric Oxide Synthase rs1799983 Gene Polymorphism and
Blood Pressure

（The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China）

Received:2016-12-19 Revised:2017-04-18 Online:2017-08-15 Published:2017-08-15

摘要/Abstract

摘要：

目的：探讨内皮型一氧化氮合成酶rs1799983多态与血压的关系。方法：在大理邀请某工厂职工参与研究，运用问卷收
集饮酒、吸烟、药物服用等信息，用SNaPshot方法进行基因分型。结果：rs1799983多态GG、GT和TT频率分别为80.3%、19.0%
和0.7%。基因型频率和等位基因频率在血压正常者和高血压患者间的差异没有统计学意义（P ≥ 0.21）。在调整协变量前后，
T等位基因携带者（GT+TT）的收缩压和脉压均显著高于GG纯合子（P ≤0.04）。进一步分析发现，rs1799983多态和低密度脂蛋
白胆固醇显著交互作用影响脉压（Pint = 0.04）。随着低密度脂蛋白胆固醇水平升高，T等位基因携带者和GG纯合子相比，脉压
显著升高。结论：内皮型一氧化氮合成酶rs1799983多态可能与血压相关，且受低密度脂蛋白胆固醇水平的影响。

关键词: 内皮型一氧化氮合成酶, 多态现象, 遗传, 血压

Abstract:

Objective：To explore the relationship between endothelial nitric oxide synthase（eNOS）rs1799983 polymorphism and
blood pressure. Methods：All employees including the retired of a factory in Dali were enrolled in the study. A standardized
questionnaire was distributed to collect information on alcohol consumption, smoking habits and use of medications. And then the
genotypes were categorized by SNaPshot method. Results：The frequencies of rs1799983 GG, GT and TT were 80.3%, 19.0% and
0.7% respectively. There was no significant difference in genotypes and alleles between participants with normal blood pressure and
hypertensive patients（P≥0.21）. However, T allele carriers（GT + TT）compared with GG homozygotes had a significantly higher
systolic and pulse pressure both before and after adjusted for covariates（P≤0.04）. It was found that significant interaction between
rs1799983 polymorphism and low- density lipoprotein cholesterol（LDL- C）had an effect on pulse pressure（Pint = 0.04）. Pulse
pressure of T allele carrier was significantly higher than GG homozygotes as LDL- C levels increased. Conclusion：The eNOS
rs1799983 polymorphism may be associated with blood pressure and affected by LDL-C levels.

Key words: nitric oxide synthase 3, polymorphism, genetics, blood pressure

中图分类号:

R544

刘洋，张庆涛，孟祥智，胡乃青，邓权亮，李利华. 内皮型一氧化氮合成酶基因rs1799983多态与血压的关系[J]. , 2017, 2(8): 23-27.

Liu Yang, Zhang Qingtao, Meng Xiangzhi, Hu Naiqing, Deng Quanliang, Li Lihua. The Relationship between Endothelial Nitric Oxide Synthase rs1799983 Gene Polymorphism and
Blood Pressure[J]. , 2017, 2(8): 23-27.

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