NRAMP1 基因3′UTR多态性位点与白族肺结核易感相关性研究

›› 2018, Vol. 3 ›› Issue (4): 64-68.

NRAMP1 基因3′UTR多态性位点与白族肺结核易感相关性研究

（大理大学第一附属医院呼吸内科，云南大理671000）

收稿日期:2018-03-28 出版日期:2018-04-15 发布日期:2018-04-15
通讯作者: 何连福，主任医师.
作者简介:王桂花，硕士研究生，主要从事呼吸系统疾病基础与临床研究.
基金资助:
云南省科技厅应用基础研究面上项目基金资助项目（2011fz295）

A Study of the Association Between 3'UTR Polymorphisms of NRAMP1 Gene and Susceptibility to Pulmonary Tuberculosis Among Bai Nationality

（Department of Respiratory, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China）

Received:2018-03-28 Online:2018-04-15 Published:2018-04-15

摘要/Abstract

摘要：

目的：探讨NRAMP1 基因3'UTR位点多态性与大理白族肺结核病易感相关性及抗结核疗效的联系。方法：采用PCRRFLP方法检测193例白族肺结核病人及191例白族健康人群的NRAMP1 基因3′UTR位点的基因型，分析其与白族人群患肺结核病的易感相关性，且对病人进行抗结核治疗1月后随访及不良反应观察，分析NRAMP1 基因多态性与病人抗结核疗效的关系。结果：NRAMP1 基因3′UTR位点GA、AA基因型均为白族患者肺结核的发病风险因子（OR=2.208和3.373，95% CI=［1.343-3.630］和［1.114-10.210］）。A等位基因与白族人群肺结核病发病呈明显正相关（OR=2.219，95% CI=［1.470-3.349］）。抗结核治疗后各基因型发生不良反应的类型及程度差异均无统计学意义（P＞0.05）。结论：NRAMP1 基因3′UTR多态性可能与大理白族人群肺结核的易感性相关。患者抗结核治疗后发生的不良反应情况与NRAMP1 基因3′UTR位点多态性无相关性。

关键词: NRAMP1基因, 大理白族, 肺结核, 基因多态性

Abstract:

Objective: To explore the correlation between the genetic polymorphism of NRAMP1 3'UTR and the susceptibility to pulmonary tuberculosis of Bai nationality in Dali. Methods: PCR-RFLP was used to analyze NRAMP1 3'UTR polymorphism of 191 TB-positive and 193 healthy people of Bai nationality living in Dali in order to study whether the gene polymrphism was correlated with the susceptibility to pulmonary tuberculosis among Bai nationality. A follow- up study was also conducted after one- month treatment to analyze whether the curative effects of treatment was correlated with the gene polymorphism. Results: Both AA and GA at NRAMP1 3'UTR（OR=2.208 and 3.373, 95% CI=［1.343-3.630］and［1.114-10.210］）were risk factors for a higher TB morbidity among Bai people. And the A allele was positively correlated with the pulmonary tuberculosis morbidity of Bai nationality（OR=2.219, 95% CI=［1.470-3.349］）. However, there was no statistically significant difference among the side -effect kinds and degrees after antituberculosis therapy（P＞0.05）. Conclusion: The polymorphism of NRAMP1 3'UTR is possibly associated with the susceptibility to pulmonary tuberculosis among Bai nationality of Dali. However, the side-effects of antituberculosis therapy do not appear to be
related to the genetic polymorphism of NRAMP1 3'UTR.

Key words: NRAMP1 gene, Bai nationality of Dali, pulmonary tuberculosis, gene polymorphism

中图分类号:

R743.32

王桂花, 何连福. NRAMP1 基因3′UTR多态性位点与白族肺结核易感相关性研究[J]. , 2018, 3(4): 64-68.

WANG Gui-Hua, HE Lian-Fu. A Study of the Association Between 3'UTR Polymorphisms of NRAMP1 Gene and Susceptibility to Pulmonary Tuberculosis Among Bai Nationality[J]. , 2018, 3(4): 64-68.

参考文献

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