经皮黄疸测定仪检测新生儿总胆红素水平的可靠性分析

大理大学学报 ›› 2021, Vol. 6 ›› Issue (4): 62-66.

经皮黄疸测定仪检测新生儿总胆红素水平的可靠性分析

黄循斌，程国强，丘惠娴

（1.深圳市龙岗中心医院新生儿科，广东深圳 518116；2.复旦大学附属儿科医院新生儿科，上海 201102）

收稿日期:2020-04-01 修回日期:2020-05-17 出版日期:2021-04-15 发布日期:2021-05-19
通讯作者: 丘惠娴，主任医师，E-mail：szlgqhx@126.com。
作者简介:黄循斌，副主任医师，主要从事新生儿危重症研究。
基金资助:
深圳市龙岗区科技创新局项目（LGKCYLWS2020009）

Reliability Analysis of Neonatal Total Bilirubin Level Determined by the Transcutaneous Jaundice Detector

Huang Xunbin, Cheng Guoqiang, Qiu Huixian

（1. Department of Neonatology, Longgang District Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, China; 2. Department
of Neonatology, Children′s Hospital of Fudan University, Shanghai 201102, China）

Received:2020-04-01 Revised:2020-05-17 Online:2021-04-15 Published:2021-05-19

摘要/Abstract

摘要： ［摘要］目的：评价经皮黄疸测定仪与全自动生化分析仪检测新生儿总胆红素（TBIL）的相关性和一致性。方法：回顾性分析
2017年6月至2019年6月在深圳市龙岗中心医院新生儿科住院治疗的新生儿高胆红素血症患儿383例。按全自动生化分析
仪检测的TBIL值分为中度黄疸组198例、重度黄疸组120例和极重度黄疸组65例。同步使用经皮黄疸测定仪和全自动生化
分析仪检测TBIL值，采用Spearman相关系数和Bland-Altman散点图分析两种检测方法TBIL值的相关性和一致性。结果：经
皮黄疸测定仪和全自动生化分析仪检测TBIL值在不同程度黄疸组比较，差异均有统计学意义（P＜0.01）。经皮黄疸测定仪和
全自动生化分析仪两种方法检测TBIL值呈显著正相关（r=0.973，P＜0.01）；两种仪器检测TBIL值的一致性较差。结论：对于
中、重度黄疸患儿经皮测定胆红素（TCB）是较好的监测工具，但是对于极重度黄疸患儿不能仅仅根据TCB进行管理，需要动态
监测血清总胆红素（STB）。

关键词: ［关键词］胆红素, 经皮黄疸测定仪, 全自动生化分析仪, 新生儿

Abstract: 〔Abstract〕Objective: To evaluate the correlation and consistency of neonatal total bilirubin（TBIL）determined by transcutaneous
jaundice detector and automatic biochemistry analyzer. Methods: We retrospectively reviewed 383 neonates with hyperbilirubinemia
who were hospitalized in the Department of Neonatology, Longgang District Central Hospital of Shenzhen from June 2017 to June 2019.
According to TBIL values detected by automatic biochemistry analyzer, the patients were divided into the moderate jaundice group with
198 neonates, the severe jaundice group with 120 neonates, and the extremely severe jaundice group with 65 neonates. The TBIL
values were determined simultaneously by transcutaneous jaundice detector and automatic biochemistry analyzer. The correlation and
consistency of TBIL values determined by the two methods were analyzed by Spearman Correlation Coefficient and Bland-Altman
Scatter Plot. Results: The differences of TBIL values of the neonates in all the groups with different degrees of jaundice determined by
the two methods were significant（P＜0.01）. There was a significant positive correlation between TBIL values detected by
transcutaneous jaundice detector and values by automatic biochemistry analyzer（r = 0.973, P＜0.01）, but the consistency of TBIL
values detected by the two instruments was poor. Conclusion: Transcutaneous bilirubin（TCB）is a better tool used to monitor children
with moderate and severe jaundice, but for children with very severe jaundice, TCB alone is not enough and dynamic monitoring of
serum total bilirubin（STB）is also needed.

Key words: 〔Key words〕bilirubin, transcutaneous jaundice detector, automatic biochemistry analyzer, neonates

中图分类号:

R722.17

黄循斌, 程国强, 丘惠娴. 经皮黄疸测定仪检测新生儿总胆红素水平的可靠性分析[J]. 大理大学学报, 2021, 6(4): 62-66.

Huang Xunbin, Cheng Guoqiang, Qiu Huixian. Reliability Analysis of Neonatal Total Bilirubin Level Determined by the Transcutaneous Jaundice Detector[J]. Journal of Dali University, 2021, 6(4): 62-66.

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