大理大学学报 ›› 2022, Vol. 7 ›› Issue (2): 39-45.

• 基础医学 • 上一篇    下一篇

PARVG基因在肾透明细胞癌患者中的表达及临床意义

王立韬12,白 丽12*   

  1. 1.大理大学基础医学院,云南大理 6710002.云南省昆虫生物医药研发重点实验室,云南大理 671000

  • 收稿日期:2021-10-29 修回日期:2021-11-17 出版日期:2022-02-15 发布日期:2022-03-29
  • 通讯作者: 白丽,教授,博士,E-mail:lbai@dali.edu.cn。
  • 作者简介: 王立韬,硕士研究生,主要从事临床肿瘤学和分子免疫学研究。
  • 基金资助:
     国家自然科学基金项目(81360319);云南省中药饮片产业发展专项资金项目(2019-YG-067

Expression and Clinical Significance of PARVG Gene in Patients with Renal Clear Cell Carcinoma

Wang Litao12 Bai Li12*   

  1. 1.Pre-clinical College Dali Yunnan 671000 China 2. Yunnan Key Laboratory of Insect Biomedicine Research and Development Dali Yunnan 671000 China

  • Received:2021-10-29 Revised:2021-11-17 Online:2022-02-15 Published:2022-03-29

摘要: 目的:基于生物信息学方法探讨PARVG基因在肾透明细胞癌(KIRC)中的表达及功能。方法:利用多种在线数据库和软件综合分析PARVG基因在KIRC中的预后价值及其相关的调控机制。结果:PARVG基因在KIRC中的表达水平显著高于癌旁正常组织(P<0.05);PARVG基因表达水平与患者不同的肿瘤分期与分级、种族、年龄等临床病理特征直接相关,且其高表达水平提示患者预后不良(P<0.05);PARVG基因的共表达基因有17个,其生物信息学功能主要富集于细胞质膜的形成及完整性的维持、细胞通讯、信号转导等多个方面。结论:PARVG基因在KIRC患者中呈现高表达,可作为KIRC患者诊断、治疗和预后的潜在靶点。

关键词: font-family:SimSun, ">肾透明细胞癌;font-family:SimSun, ">PARVGfont-family:SimSun, ">基因;生物信息学分析

Abstract:  Objective To investigate the expression and function of PARVG gene in kidney renal clear cell carcinoma KIRC based on bioinformatics. Methods A variety of online databases and software were used to synthetically analyze the prognostic value of PARVG gene in KIRC and its related regulatory mechanism. Results The expression level of PARVG gene in KIRC was significantly higher than that in normal tissues adjacent to cancer P<0.05), and the expression level of PARVG gene was directly related to the clinicopathological features of patients with different tumor stages grades ethnicities and ages and its high expression level suggested a poor prognosis P<0.05. There are 17 co-expressed genes of PARVG gene and its bioinformatics function is mainly concentrated on the formation and maintenance of plasma membrane cell communication signal transduction and so on. Conclusion PARVG gene is highly expressed in KIRC patients which can be used as a potential target for diagnosis treatment and prognosis of KIRC patients.

Key words:

 , KIRC">; PARVG">; bioinformatics analysis

中图分类号: