大理大学学报 ›› 2023, Vol. 8 ›› Issue (2): 51-55.

• 临床医学 • 上一篇    下一篇

四川省凉山地区高风险人乳头瘤病毒亚型分布研究

陈华秋1,陈兴友2,王光明3*   

  1. 1.西昌市人民医院检验科,四川西昌 6150002.西昌市人民医院病理科,四川西昌 6150003.大理大学第一附属医院基因检测中心,云南大理 671000

  • 收稿日期:2022-04-05 修回日期:2022-06-14 出版日期:2023-02-15 发布日期:2023-03-02
  • 通讯作者: 王光明,教授,博士,E-mail:wgm1991@dali.edu.cn。
  • 作者简介:陈华秋,硕士研究生,主要从事分子生物学研究。
  • 基金资助:
    凉山彝族自治州科技计划重点研发项目(21ZDYF0173

Study of the Distribution of High-Risk Human Papilloma Virus Subtypes in Liangshan Region Sichuan Province

Chen Huaqiu1 Chen Xingyou2 Wang Guangming3*   

  1. 1. Department of Laboratory Xichang People's Hospital Xichang Sichuan 615000 China 2. Department of Pathology Xichang People's Hospital Xichang Sichuan 615000 China 3. Gene Testing Center The First Affiliated Hospital of Dali University Dali Yunnan 671000 China

  • Received:2022-04-05 Revised:2022-06-14 Online:2023-02-15 Published:2023-03-02

摘要: 目的:了解四川省凉山地区女性高风险人乳头瘤病毒(HR-HPV)的感染特点,为该地区HPV疫苗开发和应用提供数据支持。方法:应用PCR-荧光探针法对20181114日至20201230日在西昌市人民医院体检中心和妇产科门诊就诊的7 445例女性行HR-HPV检测,并对检测结果进行统计分析。结果:7 445例样本中HR-HPV阳性1 027例,阳性率为13.79%15HR-HPV亚型均有检出;其中单一型感染者818例(占79.65%),多重感染者209例(占20.35%);HR-HPV感染阳性率排名前三的亚型分别为HPV 52型、16型和53型;在各个年龄段中,年龄≥61岁的受检者阳性率最高(占22.39%),其次为21~30岁的受检者(占15.86%)。结论:四川省凉山地区HR-HPV亚型感染分布具有一定的区域性,61岁以上者阳性率最高,因此应加强适龄人群HR-HPV筛查的宣传力度。

关键词: font-family:宋体, ">高风险人乳头瘤病毒, font-family:", ">PCR-font-family:宋体, ">荧光探针法, 宫颈癌

Abstract: Objective To understand the characteristics of high-risk human papillomavirus HR-HPV infection among women in Liangshan Region Sichuan Province and to provide data support for the development and application of HPV vaccine in this area.Methods The PCR fluorescence probe method was used to detect HR-HPV in 7 445 women who visited the physical examination center of Xichang People's Hospital and the outpatient department of obstetrics and gynecology from November 142018 to December 302020 and the detection results were statistically analyzed. ResultsAmong the 7 445 samples 1 027 were HR-HPV positive with a positive rate of 13.79% and all 15 HR-HPV subtypes were detected. Among them 818 cases 79.65% were single infection and 209 cases 20.35% were multiple infection. The top three subtypes of HR-HPV infection were HPV 52 16 and 53. In all age groups the positive rate of subjects aged 61 years was the highest 22.39%), followed by subjects aged 21-30 years 15.86%. Conclusion The distribution of HR-HPV subtype infection in Liangshan Region Sichuan Province has certain regional characteristics and the positive rate is the highest among people over 61 years old. Therefore it is necessary to strengthen the publicity of HR-HPV screening among the suitable age population.

Key words: font-family:Times New Roman, ">high-risk human papilloma virusfont-family:Times New Roman, ">, font-family:Times New Roman, "> PCR fluorescence probe methodfont-family:Times New Roman, ">, font-family:Times New Roman, "> cervical carcinoma

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