瓜蒌滴丸的制备及其工艺考察

›› 2018, Vol. 3 ›› Issue (4): 36-40.

瓜蒌滴丸的制备及其工艺考察

（皖南医学院药学院，安徽芜湖241002）

收稿日期:2017-09-04 修回日期:2017-09-23 出版日期:2018-04-15 发布日期:2018-04-15
通讯作者: 鄢海燕，教授.
作者简介:洪国君，硕士研究生，主要从事天然药物药理学研究.
基金资助:
安徽高校省级自然科学研究重大项目（KJ2016SD60）

Explorations of the Preparation and Process of Fructus Trichosanthis Dropping Pills

（Pharmacy School of Wannan Medical College, Wuhu, Anhui 241002, China）

Received:2017-09-04 Revised:2017-09-23 Online:2018-04-15 Published:2018-04-15

摘要/Abstract

摘要：

目的：优化瓜蒌滴丸的制备工艺。方法：以硬度、圆整度的累加值等为终评指标，根据药物与基质的质量配比、基质的选择、滴制及冷凝温度、滴头的选择及滴距、滴速等几个单因素来设计正交优化实验，进而对瓜蒌滴丸的制备工艺进行考察。结果：滴丸的最佳成型工艺为以药物与基质的质量比为1：1.5（g/g），PEG 4000：PEG 6000=1：5（g/g）为基质质量比，滴速20 d/min，滴距7 cm。结论：选取的滴丸制备工艺合理，制备的滴丸符合《中华人民共和国药典》2015年版的相关规定和要求。

关键词: 瓜蒌滴丸, 正交优化, 工艺考察

Abstract:

Objective: To optimize the preparation process of Fructus Trichosanthis dropping pills. Methods: With the cumulative value of hardness and roundness as the evaluation index, the orthogonal optimization experiment was designed according to the ratio of drug to matrix, the selection of matrix, the dropping and the condensing temperature, the selection of the dropping head, the dropping distance, the dropping speed and so on. The preparation process of Fructus Trichosanthis dropping pills was investigated. Results: The optimum forming process of dropping pills was as follows: the mass ratio of drug to matrix is 1:1.5（g/g）, PEG 4000:PEG 6000=1:5（g/g）as the matrix, and the dropping speed is 20 d/min with a dropping distance of 7 cm. Conclusion: The preparation process of the dropping pills is reasonable and the prepared dropping pills meet the relevant regulations and requirements of the 2015 edition of Pharmacopoeia of People's Republic of China.

Key words: Fructus Trichosanthis dropping pills, orthogonal optimization, process investigation

中图分类号:

TQ461

洪国君, 邹纯才, 鄢海燕. 瓜蒌滴丸的制备及其工艺考察[J]. , 2018, 3(4): 36-40.

Hong-Guo-Jun, JU Chun-Cai, YAN Hai-Yan. Explorations of the Preparation and Process of Fructus Trichosanthis Dropping Pills[J]. , 2018, 3(4): 36-40.