基于网络药理学的黄精抗糖尿病作用机制研究

大理大学学报 ›› 2019, Vol. 4 ›› Issue (2): 21-.

基于网络药理学的黄精抗糖尿病作用机制研究

徐锋，陈滕，汪祖华，黄旭龙

（贵州中医药大学，贵阳550025）

收稿日期:2018-09-03 修回日期:2018-11-02 出版日期:2019-02-15 发布日期:2019-02-15
作者简介:徐锋，博士，主要从事中药质量控制和中药药理学研究.
基金资助:
贵州省国内一流建设学科项目（中药学）（GNYL〔2017〕008号）；贵阳中医学院博士启动基金资助项目（2017，
3043-043170039）

Study on the Anti-diabetes Mechanism of Polygonati Rhizoma Based on Network Pharmacology

Xu Feng, Chen Teng, Wang Zuhua, Huang Xulong

（Guizhou University of TCM, Guiyang 550025, China）

Received:2018-09-03 Revised:2018-11-02 Online:2019-02-15 Published:2019-02-15

摘要/Abstract

摘要： ［摘要］目的：运用网络药理学方法探讨黄精抗糖尿病作用的分子机制。方法：通过TCMSP数据库获取黄精的活性成分，通过
HIT和TTD数据库筛选黄精的作用靶点，建立靶点数据集，OMIM数据库筛选糖尿病相关的靶点，PPI数据库构建黄精和糖尿病
的交互靶点，利用Cytoscape软件构建“成分-靶点-疾病”交互网络图，并通过DAVID数据库中GO和KEGG通路分析靶点功能
及信号通路。结果：筛选出黄精12个活性成分，且涉及胰岛素受体、半胱氨酸蛋白酶-3、诱导型一氧化氮合酶、雌激素受体等
17个靶点，通过调节PI3K-Akt 信号通路、AMPK 信号通路、胰岛素抵抗、胰岛素信号通路和Ⅱ型糖尿病等信号通路发挥抗糖尿
病作用。结论：黄精抗糖尿病具有多成分、多靶点、多途径的作用特点，为进一步开展黄精抗糖尿病作用的分子机制研究提供
了新思路和科学依据。

关键词: ［关键词］黄精, 糖尿病, 网络药理学, 胰岛素受体

Abstract: 〔Abstract〕Objective: To explore the anti- diabetic molecular mechanism of Polygonati Rhizoma by network pharmacology.
Methods: The active components of Polygonati Rhizoma were obtained from TCMSP database. The target of Polygonati Rhizoma was
screened by HIT and TTD databases; target dataset was established; OMIM database was used to screen the diabetes-related targets,
and PPI database was used to construct the interactive targets for Polygonati Rhizoma and diabetes. Cytoscape software was used to
construct a "component-target-disease" interactive network map, and the target function and signaling pathway were analyzed by the
GO and KEGG pathways in the DAVID database. Results: The 12 active components of Polygonati Rhizoma were screened, and the
active components of Polygonati Rhizoma were involved in 17 targets including insulin receptor, Caspase-3, inducible nitric oxide
synthase and estrogen receptor, etc. Anti- diabetic effects of Polygonati Rhizoma was regulated by multiple signaling pathways
including PI3K-Akt signaling pathway, AMPK signaling pathway, Insulin resistance, Insulin signaling pathway and Type II diabetes
mellitus. Conclusion: This study demonstrates the multi-component-multi-target-multi-pathway characteristics of Polygonati Rhizoma,
which provides a new idea and scientific basis for further research on the molecular mechanism of anti-diabetic effect of Polygonati
Rhizoma.

Key words: 〔Key words〕Polygonati Rhizoma, diabetes, network pharmacology, Insulin receptor

徐锋，陈滕，汪祖华，黄旭龙. 基于网络药理学的黄精抗糖尿病作用机制研究[J]. 大理大学学报, 2019, 4(2): 21-.

Xu Feng, Chen Teng, Wang Zuhua, Huang Xulong. Study on the Anti-diabetes Mechanism of Polygonati Rhizoma Based on Network Pharmacology[J]. Journal of Dali University, 2019, 4(2): 21-.

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