关键词: font-family:", "> , font-family:宋体, ">鞍叶羊蹄甲；急性毒性；行为学；血液生化指标；脏器指数

Abstract:

 Objective： To study the acute toxicity of Bauhinia brachycarpa on mice. Methods： Maximum dose method was applied to the acute toxicity test. After intragastrical administration of B. brachycarpa to mice， successive observation was conducted in 14 days. During administration， the body weights of the mice was determined， and the behavioral performance of the mice was assessed by voluntary activity test， balance wood test and fatigue rotarod test. The 14th day after administration， the mice were sacrificed， the organ indexes and blood biochemical indexes were measured， and the histopathological changes were observed. Results： Compared with solvent control group， the weights of the mice in B. brachycarpa group did not significantly change； the voluntary activities of the mice obviously reduced in the 1st day after administration， but had no significant changes at other observation times（Ｐ＜0.05）. There was no significant difference observed after the administration of B. brachycarpa in balance wood test and fatigue rotarod test. Nor there were any obvious variations in mice's organ indexes， histopathology and blood biochemical indexes after the administration. Conclusion： B. brachycarpa has almost no acute toxicity at the maximum dose （20 g/kg） by intragastric administration in mice which represents high safety， but its inhibitory effect on voluntary activities at the early stage of administration should be noticed.

Key words:

 , Bauhinia brachycarpa">； acute toxicity">； behavior">； blood biochemical index">； organ index