大理大学学报 ›› 2022, Vol. 7 ›› Issue (2): 57-61.

• 临床医学 • 上一篇    下一篇

阴道微环境及白介素-4与宫颈高危型人乳头状瘤病毒感染的相关研究

周源源,杜凌颖,齐梦娟,郭 颖*   

  1. (大理大学第一附属医院,云南大理 671000

  • 收稿日期:2020-09-30 修回日期:2021-03-14 出版日期:2022-02-15 发布日期:2022-03-29
  • 通讯作者: 郭颖,住院医师,E-mail:519694096@qq.com。
  • 作者简介:周源源,住院医师,主要从事围产医学及妇科肿瘤研究。
  • 基金资助:
    云南省教育厅科学研究基金项目(2020J0572);大理市科技计划项目(2019KGB019);大理大学青年教师科学研究基金项目(KYQN201517

Study on the Relationship between Vaginal Microenvironment Interleukin-4 and High-Risk HPV Infection of the Cervix

Zhou Yuanyuan Du Lingying Qi Mengjuan Guo Ying*   

  1. The First Affiliated Hospital of Dali University Dali Yunnan 671000 China

  • Received:2020-09-30 Revised:2021-03-14 Online:2022-02-15 Published:2022-03-29

摘要: 目的:研究阴道微环境及白介素-4IL-4)与宫颈高危型人乳头状瘤病毒(HR-HPV)感染的关系。方法:选取201812月至201912月大理大学第一附属医院就诊的宫颈HR-HPV感染的育龄期患者85例为观察组(A组),同期体检宫颈HPV阴性者83例为对照组(B组)。比较不同年龄段女性感染HR-HPV情况,检测阴道微环境及阴道灌洗液中IL-4水平,分析HR-HPV感染与常见阴道炎的关系,并进行多变量Logistic回归分析。结果:HR-HPV感染者中,年龄≤25岁及>45岁者感染率较26~45岁者高,差异有统计学意义(P0.05);A组与B组阴道微环境相关指标和阴道灌洗液中IL-4水平比较差异有统计学意义(P0.05);A组滴虫性阴道炎和细菌性阴道病阳性率高于B组,差异有统计学意义(P0.05);Logistic回归分析结果显示,乳酸杆菌、滴虫性阴道炎、细菌性阴道病、白细胞酯酶均是HR-HPV感染的独立危险因素。结论:HR-HPV感染存在年龄分布特点,阴道微环境及阴道灌洗液中IL-4水平升高与其分型密切相关。

关键词: font-family:SimSun, ">"> , font-family:SimSun, ">阴道微环境;阴道菌群;白介素font-family:SimSun, ">-4font-family:SimSun, ">;高危型人乳头状瘤病毒

Abstract:

Objective To study the relationship between vaginal microenvironment interleukin-4IL-4 and high-risk human papilloma virusHR-HPV infection of the cervix. Methods From December 2018 to December 2019 85 patients of childbearing age with cervical HR-HPV infection who were admitted to the First Affiliated Hospital of Dali University were selected as the observation groupGroup A), and 83 patients with cervical HPV-negative physical examination during the same period were selected as the control groupGroup B. The HR-HPV infections in women of different ages were compared the vaginal microenvironment and the level of IL-4 in vaginal lavage fluid were detected and the relationship between HR-HPV infection and common vaginitis was analyzed by multivariate Logistic regression analysis. Results Among HR-HPV infected persons the infection rate of persons 25 years old and >45 years old was higher than that of persons 26 to 45 years old and the difference was statistically significant P0.05. There were significant differences in vaginal microenvironmental indicators and the level of IL-4 in vaginal lavage fluid between Group A and Group BP0.05. The positive rates of trichomonas vaginitis and bacterial vaginosis in Group A were higher than those in Group B and the differences were statistically significantP<0.05. Logistic regression analysis showed that Lactobacillustrichomonas vaginitis bacterial vaginosis and leukocyte esterase were all independent risk factors for HR-HPV infection. Conclusion There is age distribution characteristics in HR-HPV infection. The vaginal microenvironment and the increase of IL-4 level in vaginal lavage fluid are closely related to its classification.

Key words:

vaginal microenvironment">; vaginal flora">; interleukin-4">; high-risk human papilloma virus

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