大理大学学报 ›› 2023, Vol. 8 ›› Issue (2): 62-69.

• 临床医学 • 上一篇    下一篇

Ki-67Bcl-6Bcl-2TEFM在弥漫大B细胞淋巴瘤中的表达及预后意义

孙晓梅1,梅 雯1,何 冰1,罗中贵2,孙如丽1,熊 伟2,赵 一1*   

  1. 1.楚雄彝族自治州人民医院病理科,云南楚雄 6750002.大理大学基础医学院,云南大理 671000

  • 收稿日期:2021-09-29 修回日期:2022-01-29 出版日期:2023-02-15 发布日期:2023-03-02
  • 通讯作者: 赵一,副主任医师,E-mail:yinlihua930@163.com。
  • 作者简介:孙晓梅,主治医师,主要从事肿瘤病理学研究。
  • 基金资助:
    云南省教育厅科学研究基金项目(2021J0376);国家自然科学基金项目(82160516);云南省大学生创新创业计划项目(202110679010

Expression and Prognostic Significance of Ki-67 Bcl-6 Bcl-2 and TEFM in Diffuse Large B Cell Lymphoma

Sun Xiaomei1 Mei Wen1 He Bing1Luo Zhonggui2 Sun Ruli1 Xiong Wei2 Zhao Yi1*   

  1. 1. Department of Pathology Chuxiong Yi Autonomous Prefecture People's Hospital Chuxiong Yunnan 675000 China 2. Pre-clinical College Dali University Dali Yunnan 671000 China

  • Received:2021-09-29 Revised:2022-01-29 Online:2023-02-15 Published:2023-03-02

摘要: 目的:探讨Ki-67Bcl-6Bcl-2TEFM在弥漫大B细胞淋巴瘤(DLBCL)中的表达及其与患者临床特征和预后的关系。方法:选取DLBCL组织样本41例和反应性增生淋巴组织样本42例,比较不同组织中Ki-67Bcl-6Bcl-2TEFM的表达情况;分析Ki-67Bcl-6Bcl-2TEFM蛋白表达水平与DLBCL临床病理的相关性,筛选DLBCL患者预后影响因素。结果:DLBCL组织中Ki-67Bcl-2Bcl-6表达水平明显高于非生发中心部位反应性增生淋巴组织,差异有统计学意义(P0.05);Ki-67TEFM蛋白表达水平与原发部位相关(P0.05);DLBCL患者3年生存率与患者年龄相关,年龄≥60岁的患者3年生存率仅为28.57%。结论:Ki-67Bcl-6Bcl-2DLBCL组织中高表达,TEFMKi-67Bcl-6Bcl-2DLBCL进展过程中可能具有协同作用,Ki-67Bcl-6Bcl-2可作为DLBCL预后不良的重要指标。

关键词: font-family:宋体, ">弥漫大font-family:", ">Bfont-family:宋体, ">细胞淋巴瘤, font-family:", ">Ki-67font-family:宋体, ">表达, font-family:", ">Bcl-6font-family:宋体, ">表达, font-family:", ">Bcl-2font-family:宋体, ">表达, font-family:", ">TEFMfont-family:宋体, ">表达

Abstract: Objective To explore the expression of Ki-67 Bcl-6 Bcl-2 and TEFM in diffuse large B cell lymphoma DLBCL and their relationship with the clinical characteristics and prognosis of patients. Methods The expressions of Ki-67 Bcl-6 Bcl-2 and TEFM in 41 cases of DLBCL tissues and 42 cases of reactive proliferative lymphoid tissues were compared. The correlation between the expression levels of Ki-67 Bcl-6 Bcl-2 and TEFM and the clinicopathology of DLBCL was analyzed and the prognostic factor of DLBCL patients were screened. Results The expression level of Ki-67 Bcl-2 and Bcl-6 in DLBCL tissue were significantly higher than those in non-germinal central reactive proliferative lymphoid tissueand the difference was statistically significantP<0.05. Ki-67 and TEFM protein expression levels were correlated with the primary site P<0.05. The 3-year survival rate of DLBCL patients was related to the age of patients and the 3-year survival rate of patients aged 60 years was only 28.57%. Conclusion Ki-67 Bcl-6 and Bcl-2 are highly expressed in DLBCL tissues. TEFM may have a synergistic effect on Ki-67 Bcl-6 and Bcl-2 in the progress of DLBCL. Ki-67 Bcl-6 and Bcl-2 can be used as important indicators of poor prognosis of DLBCL.

Key words: font-family:Times New Roman, ">diffuse large B cell lymphomafont-family:Times New Roman, ">, font-family:Times New Roman, "> Ki-67 expressionfont-family:Times New Roman, ">, font-family:Times New Roman, "> Bcl-6 expressionfont-family:Times New Roman, ">, font-family:Times New Roman, "> Bcl-2 expressionfont-family:Times New Roman, ">, font-family:Times New Roman, "> TEFM expression

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