Abstract: Objective: To analyze the distribution of Streptococcus pneumoniae infection, drug resistance and its changing trend in the
First Affiliated Hospital of Dali University. Methods: Sputum, alveolar lavage fluid, blood, secretions, cerebrospinal fluid, pus and bile
specimens of hospitalized patients from January 2017 to December 2019 in the First Affiliated Hospital of Dali University were isolated
and cultured, and the bacteria were identified, the drug sensitivity tested, the results determined, and the data were statistically
analyzed. Results: A total of 333 strains of Streptococcus pneumoniae were isolated, with the specimens mainly from sputum（90.99%）
of the patients in pediatrics department（53.75%）. Infants aged ≤1 year accounted for 36.64% of the total number, patients aged 1 to 18
years（including 18 years old）accounted for 19.22%, patients aged 18 to 60 years（including 60 years old）accounted for 19.52%, and
patients aged over 60 years accounted for 24.62%. Streptococcus pneumoniae accounted for 2.31% of all isolated bacteria, and its
proportion in bacterial isolation was calculated quarterly: the proportion in the first quarter（3.09%）> that in the fourth quarter（2.57%）
> that in the second quarter（2.09%）> that in the third quarter（1.77%）, but there was little difference in Streptococcus pneumoniae
separation rate between quarters. Streptococcus pneumoniae has high resistance rates to tetracycline, erythromycin and compound
sulfamethoxazole（70.40%-93.65%）, has low resistance rates to chloramphenicol, ceftriaxone, meropenem, amoxicillin, cefotaxime,
levofloxacin, telithromycin, ofloxacin, moxifloxacin（0.00%-27.20%）, and no Streptococcus pneumoniae resistant to vancomycin,
ertapenem and linezolid was found. Conclusion: Streptococcus pneumoniae was mainly isolated from sputum specimens, and the infection
cases were mainly distributed in pediatrics. Children≤1 year were the main body of infection. The separation rate of Streptococcus
pneumoniae was not significantly different among quarters. Penicillin, amoxicillin and third generation cephalosporin can be used as
first-line drugs in the treatment of pneumococcal infection in the First Affiliated Hospital of Dali University.

Key words: Streptococcus pneumoniae, clinical distribution, antibiotic resistance