J4 ›› 2011, Vol. 10 ›› Issue (6): 14-16.

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Inhibitory Efect of Scutellarin-7-o-gluronide on Gastric Cancer Cell Lines in Vitro

Objective:To study preliminarily the efect of anti-tumor activity of Scutellarin-7-0-g1u l1r0nide on gastric cancel cell lines. Methods:MTT assay was applied to investigate the inhibitmy effect of Scutellarin-7-O-glucuronide on gastric cancer cell SGC-7901 and BGC-823.Results:With Seutellarin-7-0-glucuronide concentration of 1 mg/mL,the inhibitory proportion on SGC-7901 was 47.7%, MTT results showed that there was a dose-dependence and time-dependence manner with Scutellarin-7-0-glucuronide inhibitm3,effect on SGC-7901 cell line.And there was no inhibitory efect observed on BGC-823 cell line with Scutellarin-7-o-glucuronide concentration of 1 mg/mL.Conclusion:Seutellarin-7-o-glucuronide at concentration of 1 mg/mL exhibited anti-tumor activity on SGC-791 gastric cancer cell and on  anti-tumor activity on BGC-823 cell line.   

  1. College of Pharmacy and Chemisty,Dali University,Dali,Yunnan 671 000,China)
  • Online:2011-06-01 Published:2011-06-01

Abstract:

Objective:To study preliminarily the efect of anti-tumor activity of Scutellarin-7-0-g1u l1r0nide on gastric cancel cell lines. Methods:MTT assay was applied to investigate the inhibitmy effect of Scutellarin-7-O-glucuronide on gastric cancer cell SGC-7901 and BGC-823.Results:With Seutellarin-7-0-glucuronide concentration of 1 mg/mL,the inhibitory proportion on SGC-7901 was 47.7%, MTT results showed that there was a dose-dependence and time-dependence manner with Scutellarin-7-0-glucuronide inhibitm3,effect on SGC-7901 cell line.And there was no inhibitory efect observed on BGC-823 cell line with Scutellarin-7-o-glucuronide concentration of 1 mg/mL.Conclusion:Seutellarin-7-o-glucuronide at concentration of 1 mg/mL exhibited anti-tumor activity on SGC-791 gastric cancer cell and on  anti-tumor activity on BGC-823 cell line.

Key words: scutellarin-7-o-glucuronide, MTT, gastric cancer cell

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