J4 ›› 2011, Vol. 10 ›› Issue (8): 1-4.

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Comparison of Three Methods on Drug Dissolution Based on Parameters of Weibull Distribution

Objective: To investigate different results through three methods of solving drug dissolution based on Weibull's
distribution parameter. Method: The data of drug dissolution based on Weibull's distribution were treated with statistic calculator, Microsoft Excel and SPSS software respectively. Result: T50, Td and m values were close in three methods, but ζ and t0 values were much different. Conclusion: Data from SPSS have shown highest accurate, EXCEL method was less accurate, statistic calculator was the most unreliable method.   

  1. School of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China
  • Received:2011-06-01 Revised:2011-06-07 Online:2011-08-15 Published:2011-08-15

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Abstract:

Objective: To investigate different results through three methods of solving drug dissolution based on Weibull's
distribution parameter. Method: The data of drug dissolution based on Weibull's distribution were treated with statistic calculator, Microsoft Excel and SPSS software respectively. Result: T50, Td and m values were close in three methods, but ζ and t0 values were much different. Conclusion: Data from SPSS have shown highest accurate, EXCEL method was less accurate, statistic calculator was the most unreliable method.

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