J4 ›› 2013, Vol. 12 ›› Issue (6): 31-33.

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Effects of YiShenHuoXue Decoction on TGF β1  Expression in Asthma Rats

  

  1. 1. Xi Yuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China;
    2. Affiliated Hospital of Dali University, Dali, Yunnan 671000, China
  • Received:2012-09-27 Revised:2012-11-16 Online:2013-06-15 Published:2013-06-15

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Abstract:

Objective: To investigate the effects of Yishenhuoxuepingchuan （YSHXPC）decoction on TGF β1  expression in airway
of asthma rats. Methods: Sixty health female SD rats were randomly divided into 4 groups （15 in each）: the normal group（normal
rats+saline）, the model group （athema rats+saline）, the positive control group （athema rats+hexadecadrol）, and the YSHXPC
decoction treatment group （athema rats+YSHXPV decoction）. Each group was delivered aerosol inhalation of drug every day since
the 14th day. Rats were sacrificed in the 28th day, pathological changes of lung observed by HE staining and TGF β1  expression in
lung tissue by immunohistochemical stain were conducted. Results: The results showed that the TGF β1  expression was higher in
normal group compared with other three groups. In YSHXPC decoction group, the TGF β1  expression was reduced significantly
compared with the model group and the positive control group. Conclusion: This research showed that YSHXPC decoction can
effectively inhibit the TGF β1  expression in experimental rats with asthma.

Key words: Yishenhuoxuepingchuan（YSHXPC）decoction, asthma, TGF β1

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