Abstract:

Objective: To investigate the effects of zingiber on kidney injury induced by diabetes in mice. Methods: Thirty Kunming
male mice were randomly divided into 3 groups: normal control group （C group, n=10）, diabetic model group （DM group, n=10）,
zingiber group（ZGB group, n=10）. The mice in diabetic model and zingiber group were injected 2% alloxan（90 mg/kg）from vena
caudalis to establish diabetes models. Once the mice presented with kidney injury, the ZGB group received daily intragastric
treatment of ZGB （300 mg/kg·day）, C group and DM group received daily intragastric treatment of isovolumic normal saline. The
animals were executed at 14 days of treatment. The level of blood glucose, urea nitrogen and creatinine in serum were recorded; and
the activity of super oxide dismutase （SOD）and malonaldehyde （MDA）content in kidney tissues were measured. The injury
circumstance of the kidney tissue in each group was compared by optical microscope. Results: Compared with the DM group, the
level of blood glucose, urea nitrogen and creatinine significantly decreased in ZGB group （P<0.01）; the kidney MDA content
decreased, but SOD activity of kidney rose in ZGB group （P<0.01）. Kidney cell injury in ZGB group was evidently slighter than that
of the DM group. Conclusion: Zingiber presented protective effect on kidney injury induced by diabetes in mice.

Key words: zingiber, diabetes, kidney injury, protective effect