Abstract:

Objective:To observe the anti -inflammatory effectsofthe extract in Arisaemaerubescens and explore the underlying
mechanism. Methods: Mice auricle edemawasinduced by dimethylbenzene, mice abdominal cavity capillary permeability was increased by acetic acid, and thegranuloma was induced by cotton pellet. The anti-inflammatory effectof the extract in differentmodels was observed. Results: Ethanol extract,ethyl acetate extract of Arisaemaerubescens （Wall.）Schott tuber and Petroleum ether extract of Arisaemaerubescens（Wall.）Schottfruit showed significant inhibitory action on auricle edema induced by dimethylbenzene in mice （P<0.01）and on penetration of capillary vessel in mice （P<0.01 or P<0.05）, andsignificantly decreased the proliferation of
granuloma caused by implantation cotton pellet in mice （P<0.01）Conclusion:Extract in Arisaemaerubescenshas significantantiinflammation action, which would be related to the decreased capillary permeability. The researches provided a scientific basis for the developing and utilizing of Arisaemaerubescens.

Key words: extract of Arisaemaerubescens, anti-inflammatory effect, pharmacokinetics