Protective Effect of Rubus delavayi on Alcoholic Hepatitis in Rats

Abstract

Abstract:

Objective: To research the protective effect of Rubus delavayi on hepatitis injury induced by spirit in rats. Methods: 90
rats were randomly divided into 6 groups. Rats in control group were distilled water by intragastric administered; rats in the other
groups were spirit by intragastric administered. Fill the dose for 28 days, one times a day at 8 a.m. The beginning of 15th days, rats in
each group were corresponding to a drug by intragastric administered. Fill the dose for 14 days, one times a day at 9 a.m. The
administered after blood from eyeball and to be put to death in the liver of rats. To test the activity of alanine transaminase (GPT) and
aspartate transaminase (GOT) in serum. To test the content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in
the liver tissue, and hepatic morphology were determined. Results: Rubus delavayi significantly decreased the activity of GPT、GOT
and content of MDA in serum, also increased the activity of SOD. Pathology examination showed that Rubus delavayi Franch evidently
alleviated the degeneration and necrosis of hepatic cells. Conclusion: Rubus delavayi has a protective effect on alcoholic hepatitis in
rats.

Key words: Rubus delavayi, alcoholic hepatitis, protective effect

CLC Number:

R285.5

GUO Mei-xian, YANG Yi-wen, LIU Xiao-bo, SHI Gui-rong. Protective Effect of Rubus delavayi on Alcoholic Hepatitis in Rats[J]. J4, 2014, 13(10): 1-4.

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