NF-кB Expression in Liver Carcinoma Tissues and Tissues Adjacent to Liver Cancer Tissues Post TACE

Abstract

Abstract:

Objective: To explore the expression of NF-кB in Liver carcinoma tissues and adjacent noncancerous liver tissue post
interventional therapy and its characteristic changes. Methods: 59 rabbits with VX2 carcinoma model were randomly divided into 2
groups, 29 in group A (liver cancer), and 30 in group B (liver cancer/transcatheter hepatic arterial embolization, TACE) as a study
group. And in group C 20 rabbits with no liver cancer as a control group. Immunohistochemical detection of NF-кB in liver cancer
tissue and normal tissues adjacent to liver cancer tissue was done. Results: In group A, positive expression rate of NF-κB was 72.4%
(21/29) in cancerous liver tissue and 37.9 %( 11/29) in liver tissue adjacent to carcinoma. In group B (post interventional therapy)
positive expression rate of NF-κB was 82.4% (24/30) in liver cancer tissues and 60% (18/30) in adjacent tissues. In group C, NF-κB
positive expression rate was 10% (2/20). Then each group was compared with control. Except in liver tissue adjacent to carcinoma in
group A, the data recorded was statistically significant (P < 0.05). The other two data had no statistical significance (P > 0.05).
Conclusion: The expression level of NF-κB is relatively low before interventional therapy in the tissue adjacent to carcinoma. Post
interventional therapy. There is increased expression of NF- κB, may be due to the fatty degeneration of liver tissues adjacent to
carcinoma and inflammatory reaction.

Key words: NF-кB, liver carcinoma, interventional therapy

CLC Number:

R735.7

ZHANG Liang, DU Wei. NF-кB Expression in Liver Carcinoma Tissues and Tissues Adjacent to Liver Cancer Tissues Post TACE[J]. J4, 2014, 13(10): 42-46.

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