Comparative Study on the Treatments for Hand- foot -mouth Disease in Children with Human Recombinant Interferon alph-1b and Ribavirin Respectively

Abstract

Abstract:

Objective：To discuss the effect and safety of the treatment for children's hand- foot -mouth disease with human
recombinantinterferon alph-1b. Methods：388 cases of children with hand-foot -mouth disease were randomly divided into two groups which were given the same support and symptomatic treatment. Treatment group，184 cases were treated with human recombinant interferon alph-1b，< 1，1 ug（kg·d），intramuscular，2~10 10 ug/d muscle injection，1 times a day. The control group， 204 cases were treated with ribavirin〔10~15 mg /（kg·d）〕an intravenous drip. Results：The treatment group was better than control group （P<0.01）in the defervescence time，hand，foot and skin rash and mouth ulcer healing. In addition to that the individual children have a fever；there was no obvious side effect in the treatment group. Conclusion：Interferon treatment of hand，foot and mouth disease in children is safe and effective，and is worth popularizing clinically used.

Key words: interferon, ribavirin, hand-foot- mouth disease, children

CLC Number:

R512.5

YI Jun. Comparative Study on the Treatments for Hand- foot -mouth Disease in Children with Human Recombinant Interferon alph-1b and Ribavirin Respectively[J]. J4, 2014, 13(4): 41-43.

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