Evaluation of Antimalarial Activity of the Ten Herbs from West Yunnan

Abstract

Abstract:

Objective: To study the antimalarial activity of ten herbs collected from west Yunnan for the development of new
generation of antimalarial drugs. Methods: After being milled, the plant materials were extracted three times under reflux with 75%
ethanol and water successively. The extracts were completely dried using lyophilization, and the resulting samples were tested for the antimalarial activity by β-hematin inhibition screening assay. The activities were evaluated by IC50 values. Results: Four of the ten testing plants, Metapanax delavayi, Primula denticulate, Rhododendron trichocladum, and Corylopsis himalayana, showed moderate activity to inhibit β-hematin formation with the IC50 over 1 388.9 μg/mL. Conclusion: The four plants deserved to be further studied for their potential antimalarial activity.

Key words: antimalarial activity, β-hematin inhibition assay, herbs, west Yunnan, crude extract

CLC Number:

R978.61

Liu Ziqi, Xiao Chaojiang, Zhang Xiaodong, Xu Wei, Peng Junlin, Jiang Bei. Evaluation of Antimalarial Activity of the Ten Herbs from West Yunnan[J]. J4, 2015, 14(4): 1-4.

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