Effects of Ganlong Capsule and Periplaneta americana Skim Cream on Acute Colitis in Mice

Abstract

Abstract:

Objective: To study the effect of Ganlong capsule and Periplaneta americana skim cream on acute colitis in mice and to
further observe the mechanism of action. Methods: The experiment uses the DSS modeling method to evaluate the effects of Ganlong capsule and P. americana skim cream on acute colitis through the MPO content and the observation of colon tissue TNF- α
immunohistochemical and detection of mice colon tissue of calculation of DAI. Results: Ganlong capsule and P. americana skim cream can reduce infiltration of inflammatory cytokines, reduce mucosal bleeding ulcer, glands disappeared, reduce the expression of TNF-α,the Ganlong capsule groups and P. americana skim cream groups can reduce the content of MPO in the colonic tissues（P < 0.05）.Conclusion: Ganlong capsule and P. americana skim cream have very good protection effect on acute colitis induced by DSS.

Key words: Periplaneta americana, Ganlong capsule, acute colitis

CLC Number:

R752.1+1

Niu Chunli, Zeng Jing, Xia Mengkai, Peng Fang. Effects of Ganlong Capsule and Periplaneta americana Skim Cream on Acute Colitis in Mice[J]. J4, 2015, 14(4): 12-16.

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