Abstract:

Objective: To study the effect of ethanol extracts of Xigui on model non- specific immune function of mice sleep
deprivation. Methods: Mice were randomly devided into blank control group, sleep deprivation group, positive control group, and high dose, medium dose and low dose Xigui group. Gavage normal saline was applied to the blank control group and the sleep deprivation group, Gavage ginseng drug 34.01 g/（kg·d）was applied to the positive control group, high, medium and low dose Xigui group were respectively conducted crude drug 80.88 g/（kg·d）, 40.44 g/（kg·d）, 20.22 g/（kg·d）for continuous dosing nine days. In the tenth day, the sleep deprivation group, the positive control group and high, medium, low dose Xigui group were conducted SD in plain water environment. During the period of SD, experimental drugs were given. After three days, the effect of the drugs on the non-specific immune function of SD mice was observed by the carbon clearance test. Results: The K value and α value of Xigui in high , medium,low dose group compared with the SD group are significantly increase（P＜0.05 or P＜0.01）. Conclusion: Xigui could improve the immune function of SD mice.

Key words: Xigui, sleep deprivation, immune