J4 ›› 2015, Vol. 14 ›› Issue (4): 5-7.

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Effect of the Extracts from Geranium strictipes R. Knuth on the Intestinal Propulsion Function in Mice

  

  1. 1. Pre-clinical College, Dali University, Dali, Yunnan 671000, China; 2. Yunnan Provincial Key Laboratory of Entomological
    Biopharmaceutical R＆D, Dali, Yunnan 671000, China; 3. Chuxiong Pharmaceutical College, Chuxiong, Yunnan 675000, China;
    4. College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China
  • Received:2014-12-17 Online:2015-04-15 Published:2015-04-15

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Abstract:

Objective: To study the effect of the ethyl acetate extract from Geranium strictipes R. Knuth（EAEG）on the intestinal
propulsion function in mice. Methods: Normal mice and mice of intestinal function inhibited by atropine were given different doses
EAEG for continuous 4 days, finally the propulsion distance of carbon in intestinal was measured. Results: EAEG-L（50 mg/kg）,
EAEG-M（100 mg/kg）and EAEG-H（200 mg/kg）all could increase the propulsion rate in normal mice, even the figure is up to
75.93% in EAEG-H group; in addition, EAEG-L（50 mg/kg）could improve apparently intestinal carbon propulsion rate which is
43.28%. Compared with control group, the difference is statistically significant. Conclusion: The acceleration of EGEG on intestinal
movement in normal mice and mice intestinal-inhibited by atropine may be related with M receptor.

Key words: EAEG, intestinal propulsion, carbon, atropine

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