PPAR-α Expression of Hepatocytes after TAE in Liver Cancer

Abstract

Abstract:

Objective: To investigate the function mechanism of PPAR -α in liver cancer on abnormal liver function after
transcatheter arterial embolization（TAE）. Methods: VX2 hepatic cancer model in 26 New Zealand white rabbits model were
established with 86% successful rate（24/28）. VX2 hepatic cancer models in rabbits were randomly divided to embolization group
（12）, angiography group（12）. Rabbits of very group were sacrificed 8 hours after TAE. Liver tissues surrounded HCC were collected
to make paraffin section, and the expression of PPAR-α in hepatic tissue was detected after hematoxylin & eosin（HE）staining and
immunohistochemistry. Results: Positive cells in embolization group ranged from 51%~85% with a positive assessment ++ / +++;
positive cells in angiography group were between 10%~30% with a positive assessment of + / ++. Statistical analysis showed that the
PPAR-α expression in cancer adjacent hepatic tissue of embolization group was significantly higher than angiography group（P＜
0.05）. Conclusion: After TAE, PPAR-α expression in tumor adjacent hepatic tissue increased significantly. The possible reason of
high expression of PPAR-α might be hypoxia ischemia of cancer adjacent normal tissues.

Key words: PPAR-α, liver cancer, arterial embolization, liver function

CLC Number:

R735.7

Zhang Liang,Wang Guangming, Tang Yanlong, Liu Ling, Du Wei. PPAR-α Expression of Hepatocytes after TAE in Liver Cancer[J]. J4, 2016, 1(10): 67-70.

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