Effect of Kangfuxin Solution to Ulcerative Colitis Rat Model Made by Treatment of
2, 4-Dinitrochlorobenzene Combined with Acetic Acid

Abstract

Abstract:

Objective: To explore the effect of Kangfuxin solution through enema adimistration to ulcerative colitis rat model, which
was made by the treatment of 2, 4-dinitrochlorobenzene combined with acetic acid. Methods: Ulcerative colitis rats were treated by
enema adimistration. For evaluating the effect of Kangfuxin solution on ulcerative colitis rats, the damaged intestinal mucosa and
pathological changes were observed through the determination of DAI, viscera index of rats, the expression level of serum IL-4 and IL-
10. Results: It was showed that positive medicine mesalazine and Kangfuxin solution both can improve the UC rats colon tissue
lesions, repair the damaged intestinal mucosa, decrease histologic grade markedly（P <0.01 or P <0.05）and the effect of enema is
obvious. The different doses of Kangfuxin solution can reduce DAI score, colon index and inflammation, alleviate mucosal edema and
enhance IL-4（P < 0.01）and IL-10（P < 0.01）expression level. The effect of alleviating mucosal edema and promoting healing of
ulcer surface of Kangfuxin group was improved. Conclusion: Kangfuxin solution plays an active role in treating the inflammation of UC
rats which is induced by 2,4-dinitrochlorobenzene and acetic acid, promoting the healing of UC rats colon ulcer and reducing the
diarrhea of UC rats（DAI score lower）.

Key words: Kangfuxin, mesalazine, enema, ulcerative colitis

CLC Number:

R285

Wang Pengchuan, He Miao, Zhang Hanchao, Li Guike, Li Hui，Zhang Chenggui. Effect of Kangfuxin Solution to Ulcerative Colitis Rat Model Made by Treatment of
2, 4-Dinitrochlorobenzene Combined with Acetic Acid[J]. J4, 2016, 1(4): 17-21.

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