Table of Content

15 April 2016, Volume 1 Issue 4

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Steroidal and Ceramide Constituents from Underground Part of Isodon lophanthoides

Xu Wei, Sun Junzhe, Zhao Mingzao, Wang Jingwen, Dong Xiang, Jiang Bei

2016, 1(4):  1-4. 

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Objective: To explore the chemical constituents from the underground part of Isodon lophanthoides. Methods: The
compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatography. Their structures were identified by
various spectral analysis and physicochemical properties. Results: Five steroidal compounds and two ceramide compounds were
obtained from ethyl acetate fraction of 70% acetone-water extract of the Isodon lophanthoides underground part and identified as
stigmast-4-ene-3-one（1）, stigmasterol（2）, 7α-hydroxysitosterol（3）, daucosterol（4）, 5α, 6β-dihydroxy-daucosterol（5）,（2S, 3S,
4R, 8E）-2-［（2′R）-2-hydroxytetracosanoylamino］-1, 3, 4-octadecanetriol-8-ene（6）, and 1-O-β-D-glucopyranosyl-（2S, 3R, 4E,
8Z）-2-［（2′R）-2-hydroxytetracosanoylamino］-1,3-octadecanediol-4, 8-diene（7）. Conclusion: All of these compounds except for
2 and 4 were isolated from this plant for the first time, while the compounds 5-7 were firstly obtained from the underground part of
Isodon plants.

Study on Oligosaccharide Constituents of Medicinal Plants Campylotropis Trigonoclada

Li Fengfeng, Fu Chen, Wang Fusheng

2016, 1(4):  5-7. 

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Objective: To explore the oligosaccharide constituents of Campylotropis Trigonoclada for finding bioactive natural
products. Methods: The extract water part of C. trigonoclada was chromatographied by silica gel, ODS column and LH-20 gel column
chromatography methods, and the isolates were identified based on spectroscopic analysis（1H NMR and 13C NMR）. Results: Four
oligosaccharide compounds were isolated from C. trigonoclada and characterized as［O-α-D-glucopyranosyl-（1→4）］2-O- β-Dfructofuranosyl-（
2→1）-α-D-glucopyranoside（1）, O-α-D-glucopyranosyl-（1→2）-O-［β-D-fructofuranosyl-（2→1）］2-α-Dglucopyranoside（
2）,［O-α-D-glucopyranosyl-（1→2）］2-O-［β-D-fructofuranosyl-（2→1）］2-α-D-glucopyranoside（3）and O-α-
D-glucopyranosyl-（1→2）-O-［β-D-fructofuranosyl-（2→1）］3-α-D-glucopyranoside（4）. Conclusion: Four oligosaccharide
compounds were isolated from this genus for the first time.

Study on Chemical Constituents of Campylotropis trigonoclada

Fu Chen, Li Fengfeng, Wang Fusheng

2016, 1(4):  8-13. 

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Objective: To study the chemical constituents of Campylotropis trigonoclada, aiming at searching for bioactive
ingredients. Methods: The extract part of C. trigonoclada was separated by a combination of various chromatographied including
silica gel and ODS column chromatography methods, and the isolates were identified based on spectroscopic analyses（MS, 1H NMR
and 13C NMR）. Results: Twenty compounds were isolated from C. trigonoclada and characterized as Stigmasterol（1）, β-Sitosterol
（2）, 7α- Hydroxysitosterol（3）, Oleanolic acid（4）, Ursolic acid（5）, Daucosterine（6）, Daucosterol lionleate（7）, β- Sitosterol
palmitate（8）, Isoorientin（9）, Onocerin（10）, 7-Hydroxy-4′, 6-dimethoxyisoflavone（11）, Oleic acid（12）, Hexadecane（13）,
Palmitic acid（14）, Heptacosanol（15）, Docosanoic acid（16）, Linoleic acid（17）, α-Linolenic acid（18）, D-2-O-Quebrachitol
（19）and D-Pinitol（20）. Conclusion: Compounds 1-20 were isolated from this plant for the first time.

Chemical Constituent of Swertia angustifolia Buch.II

Chu Qiao , Xia Conglong

2016, 1(4):  14-16. 

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Objective: To explore the chemical constituents of Swertia angustifolia Buch. Methods: Compounds were separated and
purified by silica gel and Sephadex LH- 20 column chromatography and their structures were elucidated on the basis of
physicochemical properties and spectral analysis. Results: Seven monomeric compounds were obtained from ethyl acetate extract of S.
angustifolia, which were characterized to be vanillic acid（1）, 1,3,8-trihydroxy-5-methoxy xanthone（2）, 5, 7, 4′-trihydroxy flavanone
（3）, 1-Hydroxy-3, 5, 6-trimethoxy xanthone（4）, methyl -3, 4-dihydroxy benzoate（5）, diisobutyl-phthalate（6）, methyl-bellidifolin
（7）. Conclusion: All seven compounds were obtained from S. angusifolia for the first time .

Effect of Kangfuxin Solution to Ulcerative Colitis Rat Model Made by Treatment of
2, 4-Dinitrochlorobenzene Combined with Acetic Acid

Wang Pengchuan, He Miao, Zhang Hanchao, Li Guike, Li Hui，Zhang Chenggui

2016, 1(4):  17-21. 

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Objective: To explore the effect of Kangfuxin solution through enema adimistration to ulcerative colitis rat model, which
was made by the treatment of 2, 4-dinitrochlorobenzene combined with acetic acid. Methods: Ulcerative colitis rats were treated by
enema adimistration. For evaluating the effect of Kangfuxin solution on ulcerative colitis rats, the damaged intestinal mucosa and
pathological changes were observed through the determination of DAI, viscera index of rats, the expression level of serum IL-4 and IL-
10. Results: It was showed that positive medicine mesalazine and Kangfuxin solution both can improve the UC rats colon tissue
lesions, repair the damaged intestinal mucosa, decrease histologic grade markedly（P <0.01 or P <0.05）and the effect of enema is
obvious. The different doses of Kangfuxin solution can reduce DAI score, colon index and inflammation, alleviate mucosal edema and
enhance IL-4（P < 0.01）and IL-10（P < 0.01）expression level. The effect of alleviating mucosal edema and promoting healing of
ulcer surface of Kangfuxin group was improved. Conclusion: Kangfuxin solution plays an active role in treating the inflammation of UC
rats which is induced by 2,4-dinitrochlorobenzene and acetic acid, promoting the healing of UC rats colon ulcer and reducing the
diarrhea of UC rats（DAI score lower）.

Analysis of 16 Kinds of Element in the Periplaneta Americana Ootheca

Tan Qiaoyun, Yang Yongshou, Li Kaifeng, Xiao Peiyun

2016, 1(4):  22-25. 

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Objective: To determine 16 kinds of element in periplaneta Americana ootheca. Methods: Perchloric acid and nitric acid
（1:4）wet digestion was applied in samples and 12 kinds of element: Co, Mg, Zn, Ni, Se, Cr, Cu, Mn, Fe, Ca, Na, K and the content of
Hg, Pb, As, Cd were determined by atomic absorption spectrophotometry and atomic fluorescence spectrophotometry respectively in
periplaneta Americana ootheca. Results: Periplaneta Americana ootheca contains plenty of essential trace elements to human, and it is
also rich in Ca, Mg, Zn, Mn, Fe and other elements. But there is no any heavy metal like Cr, Hg, Pb, As and Cd. Conclusion: To
provide basis for the further study and comprehensive utilization of periplaneta Americana ootheca.

Extraction of Polysaccharide and Content Determination of Yunnan Orchidaceae Plants

Zhao Huiran, Wang Yuzhen, Xu Ruilan, Zong Lili, Hu Jun, Guo Jie

2016, 1(4):  26-28. 

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Objective: To establish the method for determining the contents of polysaccharides and to explore the extraction
technique for polysaccharides from Yunnan orchidaceae plants. Methods: The polysaccharide was extracted with the traditional water
extraction, using glucose as the standard, and the contents of polysaccharides was measured by the phenol-sulfuric acid method. With
the content of polysaccharides as an index, the univariate test were performed to find the optimal extraction technique. Results: A good
linear relationship with a regression equation of A=55.55c（mg/mL）+0.001（r=0.999 8）was achieved when the concentration of glucose
ranged between 0.000 and 0.020 mg/mL. The average recovery rate was 99.7%, and the relative standard deviation was 3.13%（n=6）.
The best conditions of color are as follows, the dosage of phenol and sulphuric acid was 1.0 mL and 7.0 mL respectively, temperature of
color was at 80 ℃, and developing time was 30 minutes. The optimal extraction of polysaccharide was performed by 2 hours soaking
using 1 : 40 volumes of solvent at 70 ℃. Conclusion: The established method is simple and accurate and the optimal extraction
technique shows good reproducibility.

Pharmacognostical Study of Paris Vietnamensis

Duan Zhigang, Liu Jiang, Xia Conglong

2016, 1(4):  29-32. 

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Objective: To study systematicly and pharmacognostically on original plant paris vietnamensis of paris polyphylla
medicinal materials. Methods: Original plant morphology, properties, microscopy and powder were used in authenticating paris
vietnamensis, and HPLC was applied in measuring the content of its active ingredient. Results: The morphological characteristics,
rhizomes transverse section organization structures and powder characteristics of paris vietnamensis were described in detail. A good
linearity was demonstrated by in determination of saponins in paris vietnamensis. Conclusion: Through the physiochemical
identification of original plant, rhizome transection and powder for paris vietnamensis, this medicinal materials can be identified, which
can provide scientific basis of paris vietnamensis for its identification and further study.

Effect of HDAC1 siRNA on Alveolar Epithelial Type Ⅱ Cells EMT Induced by TGF-β1

Wang Weiwei, Wang Jiajia, Xu Chunhong, Guo Baiyin, Dai Baoxiu, Xu Guoping

2016, 1(4):  33-36. 

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Objective: To investigate the effect of HDAC1siRNA on phenotypic changes and function of TGF-β1-induced type Ⅱ
alveolar epithelial cells（RLE-6TN）to EMT. Methods: RLE-6TN cells were cultured and treated with HDAC1 siRNA, then TGF-β1
was added to the cells before collecting cells. The morphological changes were examined by phase-contrast microscope while the
phenotypic changes were examined by the immune fluorescence method. The protein and mRNA expression of HDAC1, HDAC8, Ecad
and α-SMA of RLE-6TN Cells were assayed by Western Blot and Real-time RT-PCR, respectively. The migration in vitro of cells
was assayed by Transwell chambers. Results: Morphologically, TGF-β1 could induce the EMT process of the RLE-6TN cells; after
transfection, cells were polygonal and like the flagstones. Under fluorescence microscope, the cells had expression of α-SMA with
increasing expression of HDAC1 in the group treated with TGF-β1, transfection group is the opposite. At the mRNA level, TGF-β1
could down-regulate the expression of E-cad with up-regulation the HDAC1 and HDAC8 expressions; after transfection, the HDAC1
and HDAC8 expressions were down-regulated with up-regulation the α-SMA expression. At the protein level, TGF-β1 could induce
the down-regulation expression of E-cad with up-regulation expression of the α-SMA and HDAC1, transfection group is the opposite.
In vitro migration ability, TGF-β1 could increase migration cells while transfection group reduced. Conclusion: HDAC1 siRNA could
partially reverse the EMT of RLE-6TN cells induced by TGF-β1 in vitro.

Clinical Observation on Treating Acute Pancreatitis with the Qingyi Decoction and Low Molecular
Dextran

Zhang Linying

2016, 1(4):  37-38. 

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Objective: To observe clinical effects of the Qingyi Decoction and low molecular dextran on acute pancreatitis. Methods:
105 patients were divided into the observe group（55 cases）and the control group（50 cases）with routine treatment, while the observe
group was given the Qingyi Decoction and low molecular dextran. Results: Effective rate in the observe group were significantly
superior to the control group（P＜0.05）. Conclusion: Qingyi Decoction and low molecular dextran treatment of acute pancreatitis show
the advantages of combining traditional Chinese and western medicine, which has a good curative effective in the actual clinical
application.

Clinical Study on Transdermal Fentanyl Used in Relieving Cancer Pain in 126 Cases

Li Yunxia, Shen Lida, Yi Zihan

2016, 1(4):  39-41. 

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Objective: To observe the clinical effect and adverse reaction of transdermal fentanyl in treating cancer pain. Methods:
126 patients with cancer pain were divided into moderate and severe cancer pain group with the treatment of transdermal fentanyl, and
the sum up the pain relief effects, adverse reactions, quality of life grading in patients received treatment. Results: Pain of those
patients had relived at some degrees. For moderate group, CR is 57.0%; for severe group, CR is 54.5%. The difference is statistical
significant.There was no severe averse events occurred such as dizziness, constipation, nausea, drowsiness and cutaneous pruritus.
Conclusion: Transdermal fentanyl were convenient, effective and with minor averse events in managing cancer pain clinically.

Comparative Study of Clinical Effect of Laparoscopic Radical Gastrectomy and Traditional Open
Gastrectomy

Li Meng, Shao Yu, Shu Wuying, Tan Yunbo

2016, 1(4):  42-45. 

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Objective: To compare clinical results of gastric cancer patients undergoing laparoscopic radical and traditional open
gastrectomy. Methods: The clinical effect of 103 gastric cancer patients undergoing laparoscopic radical gastrectomy and traditional
open gastrectomy in Affiliated Hospital of Dali University from October 2010 to October 2013 were summarized and analyzed. Results:
Laparoscopic radical gastrectomy resulted in significantly less blood loss volume（153.05±11.71）mL vs.（278.45±12.65）mL,（P <
0.05）, less anal exsufflation time（3.10±0.62）d vs.（5.58±1.12）d,（P < 0.05）, shorter postoperative hospital stay（14.25±2.78）d
vs.（22.07±3.59）d,（P <0.05）and higher survival rate of one year（94.1% vs. 92.1%, P > 0.05）. Conclusion: Laparoscopic radical
gastrectomy enjoys advantages like less blood loss volume, less postoperative hospital stays, less postoperative complications and
favorable clinical effect comparing with open gastrectomy.

The Application of Continuous Douche Combined with VSD in the Treatment of Perforating Wounds by
Rotary Cultivators

Bai Tao, Na Qiang, Xu Lifen, Zhao Hui, Wang Guozhu

2016, 1(4):  46-49. 

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Objective: To discuss the differences between the applications of continuous douche combined with vacuum sealing
drainage（VSD）and traditional open wound and indwelling drainage to treat the patients whose limbs are penetratingly wounded by the
blades of rotary cultivators, covering the aspects of inflection rates, patients' pains, the length of stay in hospital and the hospitalization
expanses. Methods: 52 cases in which the patients' arm or leg was perforated by the blades of rotary cultivators were chosen. Among
them, 25 cases were conducted by the way of traditional open wound and indwelling drainage as A group. Rest 27 cases were treated by
the way of continuous douche combined with VSD as B group. Results: The patients in B group had lower inflection rates than A group
（P<0.05）. The VAS score of B group staying in hospital after the operation was lower than that of A group（P<0.05）. The length of stay
in hospital of B group was shorter than that of A group（P<0.05）. There was no obvious difference at hospitalization costs between A
group and B group（P>0.05）. Conclusion: The therapeutic methods of A group and B group had gained a good result, the patients all
had recovered. There was no obvious difference in the hospitalization costs, but B group was better than A group at the aspects of lower
inflection rates, less patients' pains and shorter length of staying in hospital.

Littoral Cell Angioma of the Spleen: A Case Report and Literature Review

Shao Yu, Tan Yunbo

2016, 1(4):  50-51. 

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Objective: To investigate the clinicopathologic features and the main points of diagnosis of littoral cell angioma（LCA）of
spleen. Methods: The clinical features, radiologic findings and histopathologic changes were analyzed in a case of littoral cell angioma
of spleen. Immunohistochemical study was carried out and relevant literature were reviewed. Results: Histologically, the lesions
consisted of anastomosing ascular channels with papillary and few had cavernous appearance. And the vessels containing much of
different fibrous tissue. LCA is often studied combining with visceral cancer in foreign literature. Conclusion: LCA is a rare angiogenic
tumors from the littoral cell of spleen, whose diagnosis is on the basis of microscopic and immunohistochemical features. There is
correlation with LCA and malignancy, and it should be closely observed with long-term follow-up.

The Application of Endoscopic Third Ventriculostomy in the Treatment of Obstructive Hydrocephalus

Zhao Dehao

2016, 1(4):  52-54. 

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Objective: To investigate the experience and effect of endoscopic third ventriculostomy in the treatment of obstructive
hydrocephalus. Methods: Retrospective analysis was introduced to 16 cases of obstructive hydrocephalus received endoscopic third
ventriculostomy in our hospital from January 2014 to February 2015. Results: All 16 cases of obstructive hydrocephalus accepted
endoscopic third ventriculostomy with 15 cases completed the surgery and one case shifted to ventriculo-peritoneal shunt. A 4-12-
month follow-up showed symptomatic improvement in 12 cases（75%）, no change in two cases, relapse in one cases and relief by
ventriculo-peritoneal shunt in one case; CT and MRI head revealed that ventricle reduced in seven cases（43.7%）, no obvious change
in seven cases, slightly expansion in two cases. Conclusion: Endoscopic third ventriculostomy is a minimal invasive approach with
obvious efficacy and less complications to obstructive hydrocephalus.

Clinical Observation of Bevacizumab in the Treatment of Diabetic Macular Edema

Duan Zhiguang, Jia Yunqin, Mo Ni, Yu Liyun, Chen Yingchao, Liu Min, Pu Shixue, Z

2016, 1(4):  55-59. 

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Objective: To evaluate the clinical effect and safety of intravitreal injection of bevacizumab in the treatment of diabetic
macular edema. Methods: The records of 26 eyes of 22 patients treated with intravitreal injection of 1.75mg bevacizumab for diabetic
macular edema were retrospectively analyzed. Best corrected visual acuity（BCVA）, intraocular pressure, choroidal leaks, central
retinal thickness（CFT） 1, 2, 3 months and 6 months before and after the treatment were analyzed and compared. Follow- up
observation were carried out among all cases after 6 months. Results: 26 eyes of 22 patients with the average of（57±18.56）years old
were included. The mean baseline of BCVA, CFT were（logMAR 0.82±0.63）,（624.2±176.1）μm respectively. Although there was no
significant decrease in mean CFT one week after the injection, the mean BCVA had significant improvement. At the last visit of 9.8
months' follow up, BCVA and CFT showed significant improvements over baseline values, which had a significant difference（P<
0.001）. BCVA was improved by at least two lines in 22 eyes（84.6%）, remained stable in 2 eyes（7.7%）at the last visit. A total of 92
injections were performed and the average number of injections was（3.98±1.52）in the group. Conclusion: Intravitreal injection of
bevacizumab can improve the visual acuity, reduce macular edema and choroidal leakage in patients with diabetic macular edema.
Repeated treatment has better effect, but a prolonged treatment effect needs further observation.

Clinical Analysis of 87 Cases of Surgical Correction of Congenital Blepharoptosis

Zhao Huiqiong

2016, 1(4):  60-63. 

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Objective: To compare the corrective effects of shortening and advancement of levator palpebrae superioris muscle and
frontal muscle flap suspension surgery for congenital blepharoptosis. Methods: Frontal muscle flap suspension surgery was adopted on
43 eyes of 33 patients and shortening and advancement of levator palpebrae superioris muscle was used on 66 eyes of 54 patients
among 87 cases by pure double eyelid incision. Follow-up visits of each patient were paid in the first, the sixth, the twelfth month after
the surgery for taking records of visual acuity, position of upper eyelid skin edge of the surgery eye, the symmetry of both eyes'
palpebral fissure, the level of palpebral fissure dysraphism, and any trichiasis and angulation deformity. Results: 79 patients got
satisfying effects and 6 patients got fine effects after the first surgery. 2 patients got insufficient correction after the first surgery and
then got satisfying effects by the second time. There is no overcorrection and nullity. Conclusion: Both of the operation methods had
positive effects. Shortening and advancement of levator palpebrae superioris muscle fits for physiology, and the level of palpebral
fissure dysraphism after the surgery was rather low and could disappear gradually. Most of the patients could choose this method but
few patients got insufficient correction. Frontal muscle flap suspension surgery has a serious level of palpebral fissure dysraphism after
the surgery and it could exist permanently. A few patients has complication of bleeding and wound dehiscence, which could be
prevented from happening with proper postoperative observation and nursing.

Investigation on the Cutoff Point for Glycosylated Hemoglobin in Dali Region

He Yingchun, Zhu Xingcheng, Yin Bo, Wang Dongju

2016, 1(4):  64-66. 

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Objective: To investigate the feasibility of hemoglobin A1C（HbA1C）diagnosing type 2 diabetes mellitus and Impaired
Fasting Glucose（IFG）, and determine the diagnostic cut point. Methods: Oral Glucose Tolerance Test（OGTT）and HbA1C were
detected in patients with 332 cases of type 2 diabetes mellitus（T2DM） and 175 cases of Impaired Fasting Glucose. Receiver
Operating Characteristic Curve（ROC）was used to determine the optimal HbA1C diagnostic cutoff point for type 2 diabetes mellitus.
Results: The FBG and HbA1C levels of the IFG and T2DM group were higher than normal healthy control group with statistical
significance（P<0.05）. According to ROC, the optimal cutoff point of HbA1C for the diagnosis of type 2 diabetes mellitus was 6.25%,
and its sensitivity was 86.5%, its specificity 95.2%, the AUC was 0.959（95% CI: 0.945-0.973）. Conclusion: The optimal cutoff point
of HbA1C for the diagnosis of Impaired Fasting Glucose was 5.51%, and the optimal cutoff point of HbA1c for the diagnosis of type 2
diabetes mellitus was 6.25%. HbA1C is an available parameter in diagnosing T2DM.

Targeted Surveillance and Prevention Analysis of MDRO Infection
in People's Hospital of Dehong Prefecture

Yang Yanqiu, Yi Wei, Chen Yanhua

2016, 1(4):  67-70. 

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Objective: To provide medical support for effective control of multidrug- resistance organism（MDRO）infection by
retrospectively analyzing targeted surveillance results and the distribution of MDRO in the hospital. Methods: Targeted surveillance
was conducted from January 2011 to December 2014 to monitor MRSA, VRE, MDR－AB, MDR－PA and ESBLs-producing strains.
Results: A total of 12 257 strains of pathogenic bacteria were isolated from January 2011 to December 2014, and 1 656 strains of
MDRO were detected, which were 13.51% of all of the isolated strains（1 656/12 257）. Among all of the 1 656 strains, the major
specimen types were urine, sputum, secretions and blood. ESBLs-producing Escherichia Coli and Klebsiella Pneumoniae were the
primary germs. MDRO infection occurred most frequently in Neurosurgery and Urology. Conclusion: ESBLs-producing strains were
still the primary MDRO from January 2011 to December 2014. The infection rates of MDR-AB showed an increasing trend and MRSA
a decreasing trend.

Effect of Interventional Treatment for Hypersplenism with Ethanol as the Embolization Material

Wang Yongping, Yi Wei, Liu Can, Zhang Rongshun, Fei Lihu, Yuan Guibin, Chai Hua,

2016, 1(4):  71-73. 

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Objective: To observe the therapeutic effect and complications of Partial Splenic Embolization（PSE）in the treatment of
hypersplenism with ethanol as the embolization material. Methods: Ethanol, as an embolization material, was used in the treatment of
32 cases of cirrhosis portal hypertension with PSE with 2.0 mL ethanol for 4 cases, 2.5 mL for 4 cases, 3.0 mL for 3 cases, 2.5 mL for
the rest 21 cases. Efficacy, complications, and quality control effect were analyzed among all cases. Results: 32 cases of PSE were
successful for the first time. The use of 2.5 mL ethanol embolization was more appropriate（average 513 mL, about area 61%）with
less adverse reactions, fewer complications, and no splenic infection. Conclusion: PSE reached a satisfied result using the 2.5 mL
fixed amount of ethanol to treat the hypersplenism with mild side reaction, few complications, simple process and low cost.

Application of DNA Quantitative Cytology Combined with Thinprep Cytologic Test in Screening Cervical
Carcinoma

Zhao Lixian, Tian Linbo, Cha Jinyan, Wang Guangming

2016, 1(4):  74-77. 

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Objective: To investigate the efficiency of DNA quantitative cytology and Thinprep Cytologic Test in screening cervical
carcinoma and analyze the relationship between these two methods. Methods: 989 cases using above two screening cervical carcinoma
techniques from May 2014 to June 2015 were retrospectively analyzed. Results: 40 positive cases（4.0%）and 66 borderline cases
（6.7%）were detected through DNA quantitative cytology ; 10 positive cases（1.0%）and 42 borderline cases（4.2%）were diagnosed
through Thinprep Cytologic Test. There were some overlapping cases between these two methods. Conclusion: The positive rate of
DNA quantitative cytology was higher than that of Thinprep Cytologic Test（P＜0.05）. The combination of DNA quantitative cytology
and Thinprep Cytologic Test could provide high positive rate.

Analysis of Early Ectopic Pregnancy by Transvaginal Ultrasonography

Ma Hongmei, Li Yulan, Ji Shoulian

2016, 1(4):  78-79. 

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Objective: To analyze the value of diagnosing ectopic pregnancy by Transvaginal ultrasonography. Methods: 154 patients
in Affiliated Hospital of Dali University were diagnosed with ectopic pregnancy by transvaginal ultrasonography diagnosing, operations
and pathological results. Results: In 154 cases, 148 cases were ectopic pregnancy, 72 cases were non rupture, 86 cases were ruptured,
and 6 cases were ruptured corpus. Conclusion: Transvaginal ultrasonography diagnosis of ectopic pregnancy, which has a high
accuracy, combined with clinical history and blood HCG, can make early diagnosis of ectopic pregnancy, and provide reliable and
timely diagnosis basis for clinical treatment.

Clinical Observation of HAART in HIV/AIDS Patients of MSM

Guo Yingwu, Bai Jingsong, Liu Jun, Wang Weibo, He Rong, Hou Wei

2016, 1(4):  80-82. 

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Objective: To explore the effectiveness of Highly Active Antiretroviral Therapy（HAART）in men who have sex with men
（MSM）. Methods: 224 AIDS adults cases of MSM had been treated with the Highly Active Antiretroviral Treatment from 2006 to 2013
for more than one year, and immune reconstruction, viral load, the HIV test of spouse, the rate of condom using and number of sexual
partners were analyzed statistically before and after treatment. Results: The viral load in the 224 AIDS cases was apparently controlled
（＜50 copies/mL）and the level of CD4+ T cell was apparently increased. The unsafe sex rate and the number of sexual partners were
declined（P＜0.01）. Conclusion: HIV patients of MSM were effectively controlled through HAART and patient compliance, and the
awareness of safe sex of the MSM patients apparently improved, which showed the remarkable effect in prevention and control of HIV
spreading from MSM infected to the general population.

Correlation Study on Self-management Behaviors and Self-efficacy in Patients Receiving Maintenance
Hemodialysis

Xia Linjuan, Zhao Yuan

2016, 1(4):  83-86. 

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Objective: To describe patients' self-management behaviors and self-efficacy and determine the correlation between
them in patients receiving maintenance hemodialysis. Methods: A questionnaire survey was conducted among 175 patients receiving
maintenance hemodialysis with self-management behavior questionnaire and chronic disease self-efficacy scale. Results: A positive
correlation between patients' self-management behaviors and self-efficacy is with statistical significance（P < 0.05 or P < 0.01）.
Conclusion: The level of self-management behaviors and self-efficacy in hemodialysis patients need to be elevated. Strategy for
psychological health with the self-efficacy as the core can be carried out for improving the self-management behaviors levels of
hemodialysis patients.

Analysis of Application of Colostomy Skin Tool in the Ileum Colostomy Nursing

Yang Aihua, Qin Yahui

2016, 1(4):  87-89. 

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Objective: To explore effect of the colostomy skin tool in the ileum colostomy nursing, including DET assessment and
AIM guide. Methods: The DET assessment of colostomy skin tool was used to assess the surrounding skin problems of ileum of
colostomy patients. The type and reason of skin problems were diagnosed on the basis of the content of AIM nursing guide. Targeted
nursing intervention was conducted in patients with ileum colostomy and the intervention results were analyzed in return visit. Results:
The DET total score of newly diagnosed skin problems around the stoma was（4.84 ± 2.44）, while total score was（1.53 ± 0.51）（P <
0.05）in return visit, which showed that the difference before and after the intervention was statistically significant. Conclusion: The
use of colostomy skin tools DET assessment and AIM guide to evaluate colostomy surrounding skin problems and corresponding
nursing instruction can effectively improve the surrounding skin condition of ileum colostomy patients and reduce the incidence rate of
skin around the colostomy complications, which was worthy of further promoting and applying in clinic.

Exploration of Nursing Disputes in Emergency Department

Wu Yongli

2016, 1(4):  90-91. 

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Objective: To summarize the causes of nursing dispute in Emergency Department and to provide precautions. Methods:
Based on the service attitude and operation skills, this paper analyses the cause of nursing dispute and provides precautions. Results:
Nursing quality and relationship between nurse and patient were improved; meanwhile, nursing disputes decreased dramatically.
Conclusion: The improvement of nurse theory, morality and professional skill is an effective way to avoid nursing disputes.

Participatory Evaluation of Education Effect about AIDS Prevention among Medical College Students

Chen Yuanling, Su Lina

2016, 1(4):  92-94. 

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Objective: To investigate the feasibility of developing participatory education of AIDS prevention among medical college
students. Methods: Clinical medicine students in two classes were randomly selected and the changes before and after training were
analyzed through the questionnaire survey. Results: The subjects were（19.04±0.80）years old, and 476 effective questionnaires were
collected before and after training. Scores of AIDS knowledge, attitude and behavior before training were（12.20 ± 2.89）,（5.07 ± 1.87）,
（10.71±3.33）; and scores rising to（14.22±1.16）,（12.99±1.73）,（13.28±1.54）（P<0.05）after training. AIDS awareness was 62.6%
before training, and 98.7%（P<0.05）after training. Conclusion: It is feasible to carry out participatory education among medical
students, and implementation of peer education with it can further improve and develop the participatory education.

Survey on Teaching Quality and Efficiency of Biological Materials Inspection

Yang Yixing, Song Yanqiu, Wang Jiacheng, He Zoushun, Shen Yuanying

2016, 1(4):  95-97. 

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Objective: To understand teaching quality and efficiency of Biological Material Inspection course and students' demand,
which may provide theoretical basis for course reform and talent cultivation. Methods: 180 undergraduates who major in Health
Inspect were selected randomly as research objects. All participants were required to fill the questionnaires that included teaching
quality evaluation, curriculum satisfaction and demand part on the course. Results: Total number of valid questionnaires was 165 and
valid proportion was 98%. The overall score that reflects teaching quality of the course was（88.4 ± 8.4）. Scores of attitude of teacher,
theoretical education and practice, technical methods as well as effect were（14.1±1.1）,（17.1 ± 1.8）,（17.9 ± 1.8）,（22.2±2.3）and
（17.1±2.7）, respectively. Overall score of teaching quality score in different grades was not statistically significant（F=101, P<0.001）.
Conclusion: Teaching quality of the course has been decreasing in recent years, which shows the significance of improving and
strengthening the construction of the online course and bilingual teaching platform.

Comparative Study of Professional Identity between Free Medical Students and Non-free Medical
Students：A Case Study in Dali University

Zhang Jie, Qian Rong, Li Qian, Fu Yirong, Yang Yongfu, Ni Hongxia, He Yutao

2016, 1(4):  98-100. 

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Objective: To strengthen free medical students' professional identity, effectively promote the medical students free
education, and put forward and improve the system of free medical students education through a comparative study of free medical and
non-free medical students' professional identity status. Methods: Richter five points method was adopted to design the questionnaire
and complete the data collection from October 2014 to May 2015. Results: Free medical and non-free medical students' professional
identity status did not differ significantly, and different grade medical students' professional identity presented by the regular change
from high to low. Conclusion: Responsibility consciousness should be clear through enhancing vocational education. Process
management should be strict through establishing constraint mechanism. It's necessary to explore the incentive mechanism and to
adjust policy timely to improve the system of free education for medical students.